Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMPR1B | O00238 | 4/20 | 0.62 |
| ▸ | BMPR1A | P36894 | 4/20 | 0.62 |
| ▸ | ACVRL1 | P37023 | 4/20 | 0.62 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.62 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.62 |
| ▸ | MERTK | Q12866 | 5/20 | 0.58 |
| ▸ | AXL | P30530 | 3/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.54 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | MET | P08581 | 3/20 | 0.49 |
| ▸ | CCNC | P24863 | 1/20 | 0.49 |
| ▸ | CDK8 | P49336 | 1/20 | 0.49 |
| ▸ | ACACB | O00763 | 1/20 | 0.48 |
| ▸ | ACACA | Q13085 | 1/20 | 0.48 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18612197 | 0.91 | MERTK (0.59) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL18615504 | 0.90 | BMPR1B (0.68) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL18616326 | 0.85 | BMPR1B (0.57) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL18611892 | 0.81 | MERTK (0.55) | MERTKAXLL3MBTL3L3MBTL1MET | |
| SCHEMBL21779411 | 0.80 | AXL (0.60) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL21779417 | 0.80 | MERTK (0.64) | MERTKAXLL3MBTL3L3MBTL1 | |
| SCHEMBL10380840 | 0.79 | L3MBTL3 (0.59) | MERTKAXLL3MBTL3L3MBTL1MET | |
| SCHEMBL18612199 | 0.79 | L3MBTL3 (0.59) | MERTKAXLL3MBTL3L3MBTL1MET | |
| SCHEMBL18615821 | 0.79 | MERTK (0.58) | MERTKAXLL3MBTL3L3MBTL1MET | |
| SCHEMBL18617156 | 0.78 | PIK3C3 (0.59) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3344613-B1 | HETEROARYL COMPOUNDS AND THEIR USE AS THERAPEUTIC DRUGS | DONG A SOCIO HOLDINGS CO LTD (KR) | 2020-03-04 | — | — | EP | disclosed |
| WO-2017039331-A1 | HETEROARYL COMPOUNDS AND THEIR USE AS THERAPEUTIC DRUGS | DONG-A SOCIO HOLDINGS CO., LTD. (KR) | 2017-03-09 | — | — | WO | disclosed |