Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | GPR142 | Q7Z601 | 4/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CHKA | P35790 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21780458 | 0.83 | GPR142 (0.37) | SIGMAR1GPR142CD274ROCK2ROCK1 | |
| SCHEMBL14480719 | 0.74 | CA9 (0.40) | SIGMAR1GPR142CD274ROCK2ROCK1 | |
| SCHEMBL21780434 | 0.71 | KCNH2 (0.46) | GPR142ROCK2ROCK1CYP3A4CYP2D6 | |
| SCHEMBL25955644 | 0.66 | PDE10A (0.43) | GPR142CYP3A4CYP2D6CYP2C9KCNH2 | |
| SCHEMBL14480774 | 0.63 | KCNH2 (0.67) | GPR142ROCK2ROCK1CYP3A4CYP2D6 | |
| SCHEMBL18948145 | 0.63 | KCNH2 (0.42) | GPR142ROCK2ROCK1CYP3A4CYP2D6 | |
| SCHEMBL22563248 | 0.62 | TLR8 (0.36) | SIGMAR1GPR142CD274ROCK2ROCK1 | |
| SCHEMBL3310122 | 0.61 | BRD4 (0.47) | — | |
| SCHEMBL14353694 | 0.61 | GPR142 (0.59) | GPR142ROCK2ROCK1CYP3A4CYP2D6 | |
| SCHEMBL14353582 | 0.61 | PIK3CA (0.48) | GPR142ROCK2ROCK1CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3101013-B1 | FUSED BENZOXAZEPINONES AS ION CHANNEL MODULATORS | GILEAD SCIENCES INC (US) | 2020-10-21 | — | — | EP | disclosed |
| EP-3085696-B1 | FUSED BENZOXAZEPINONES AS ION CHANNEL MODULATORS | GILEAD SCIENCES INC (US) | 2020-03-04 | — | — | EP | disclosed |