Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.46 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.46 |
| ▸ | SCN1A | P35498 | 1/20 | 0.46 |
| ▸ | SCN4A | P35499 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.46 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.46 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.46 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.36 |
| ▸ | GPR142 | Q7Z601 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21780458 | 0.85 | GPR142 (0.37) | KCNH2SCN5ASCN1ASCN4ASCN9A | |
| SCHEMBL21780452 | 0.77 | KCNH2 (0.41) | KCNH2SCN5ASCN1ASCN4ASCN9A | |
| SCHEMBL14480838 | 0.74 | KCNH2 (0.71) | KCNH2SCN5ASCN1ASCN4ASCN9A | |
| SCHEMBL22563269 | 0.73 | KCNH2 (0.45) | KCNH2SCN5ASCN1ASCN4ASCN9A | |
| SCHEMBL14480844 | 0.73 | KCNH2 (0.47) | KCNH2SCN5ASCN1ASCN4ASCN9A | |
| SCHEMBL21780485 | 0.72 | CA12 (0.41) | KCNH2SCN5ASCN1ASCN4ASCN9A | |
| SCHEMBL21780438 | 0.71 | SIGMAR1 (0.35) | KCNH2CA12CA9ROCK2ROCK1 | |
| SCHEMBL14480907 | 0.68 | KCNH2 (0.63) | KCNH2SCN5ASCN1ASCN4ASCN9A | |
| SCHEMBL18290467 | 0.67 | KCNH2 (0.71) | KCNH2SCN5ASCN1ASCN4ASCN9A | |
| SCHEMBL14480602 | 0.67 | SCN1A (0.76) | KCNH2SCN5ASCN1ASCN4ASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3085696-B1 | FUSED BENZOXAZEPINONES AS ION CHANNEL MODULATORS | GILEAD SCIENCES INC (US) | 2020-03-04 | — | — | EP | disclosed |