Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR142 | Q7Z601 | 4/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21780434 | 0.85 | KCNH2 (0.46) | GPR142ROCK2ROCK1KCNH2CYP3A4 | |
| SCHEMBL21780438 | 0.83 | SIGMAR1 (0.35) | GPR142ROCK2ROCK1KCNH2CYP3A4 | |
| SCHEMBL14481129 | 0.71 | CA9 (0.43) | GPR142ROCK2ROCK1KCNH2CYP3A4 | |
| SCHEMBL14353978 | 0.65 | GPR142 (0.39) | GPR142ROCK2ROCK1KCNH2CYP3A4 | |
| SCHEMBL21780433 | 0.64 | GPR142 (0.48) | GPR142CYP2D6PIK3CACA9CA12 | |
| SCHEMBL14354046 | 0.63 | GPR142 (0.50) | GPR142ROCK2ROCK1KCNH2CYP3A4 | |
| SCHEMBL16986534 | 0.63 | SIGMAR1 (0.39) | GPR142ROCK2ROCK1KCNH2CYP3A4 | |
| SCHEMBL14353750 | 0.63 | GPR142 (0.49) | GPR142ROCK2ROCK1KCNH2CYP3A4 | |
| SCHEMBL14353694 | 0.63 | GPR142 (0.59) | GPR142ROCK2ROCK1KCNH2CYP3A4 | |
| SCHEMBL14353582 | 0.63 | PIK3CA (0.48) | GPR142ROCK2ROCK1KCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3101013-B1 | FUSED BENZOXAZEPINONES AS ION CHANNEL MODULATORS | GILEAD SCIENCES INC (US) | 2020-10-21 | — | — | EP | disclosed |
| EP-3085696-B1 | FUSED BENZOXAZEPINONES AS ION CHANNEL MODULATORS | GILEAD SCIENCES INC (US) | 2020-03-04 | — | — | EP | disclosed |