Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | CHRNA1 | P02708 | 2/20 | 0.34 |
| ▸ | CHRNG | P07510 | 2/20 | 0.34 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.34 |
| ▸ | CHRND | Q07001 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19152658 | 0.85 | OPRL1 (0.44) | SLC6A3SLC6A2ALOX5OPRL1OPRM1 | |
| SCHEMBL19152660 | 0.83 | OPRL1 (0.55) | OPRL1OPRM1OPRK1 | |
| SCHEMBL22112324 | 0.80 | SLC6A4 (0.62) | SLC6A3SLC6A4SLC6A2OPRL1OPRM1 | |
| SCHEMBL11095398 | 0.76 | SLC6A3 (0.47) | SLC6A3SLC6A4SLC6A2ALOX5OPRL1 | |
| SCHEMBL19094000 | 0.75 | OPRL1 (0.48) | SLC6A3SLC6A4SLC6A2OPRL1OPRM1 | |
| SCHEMBL19094002 | 0.75 | OPRL1 (0.48) | SLC6A3SLC6A4SLC6A2OPRL1OPRM1 | |
| SCHEMBL22540302 | 0.72 | OPRM1 (0.38) | SLC6A4SLC6A2OPRL1OPRM1 | |
| SCHEMBL22540358 | 0.71 | SLC6A4 (0.40) | SLC6A3SLC6A4SLC6A2OPRL1OPRM1 | |
| SCHEMBL22112502 | 0.70 | SLC6A3 (0.47) | SLC6A3SLC6A4SLC6A2OPRL1OPRM1 | |
| SCHEMBL30747360 | 0.68 | CHRM2 (0.41) | SLC6A3SLC6A4SLC6A2ALOX5OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3402781-B1 | 3-((HETERO-)ARYL)-8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2020-03-04 | — | — | EP | disclosed |