Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.53 |
| ▸ | ATM | Q13315 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 2/20 | 0.47 |
| ▸ | CNR2 | P34972 | 2/20 | 0.47 |
| ▸ | NMT1 | P30419 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | ESR1 | P03372 | 2/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.44 |
| ▸ | GRM6 | O15303 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21780873 | 0.87 | ESR1 (0.51) | TDP1NPC1SLC6A2SLC6A3KMT2A | |
| SCHEMBL21780715 | 0.87 | LMNA (0.47) | TDP1L3MBTL1ATMNPC1SLC6A2 | |
| SCHEMBL21940625 | 0.83 | KMT2A (0.50) | TDP1L3MBTL1ATMNPC1SLC6A2 | |
| SCHEMBL6411022 | 0.77 | L3MBTL1 (0.54) | TDP1L3MBTL1ATMNPC1KMT2A | |
| SCHEMBL9660322 | 0.74 | NMT1 (0.57) | TDP1NPC1SLC6A2SLC6A3KMT2A | |
| SCHEMBL12971457 | 0.74 | TDP1 (0.49) | TDP1L3MBTL1ATMNPC1KMT2A | |
| SCHEMBL7469390 | 0.74 | NMT1 (0.41) | TDP1L3MBTL1ATMNPC1SLC6A2 | |
| SCHEMBL11552702 | 0.72 | CNR1 (0.64) | TDP1KMT2ACNR1CNR2LMNA | |
| SCHEMBL22701856 | 0.72 | ALDH1A1 (0.55) | TDP1L3MBTL1SLC6A2SLC6A3KMT2A | |
| SCHEMBL9384765 | 0.71 | L3MBTL1 (0.48) | TDP1L3MBTL1ATMNPC1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233828-B1 | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2020-03-04 | — | — | EP | disclosed |