Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.48 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27635898 | 0.85 | LMNA (0.55) | PKMLMNATP53RXFP1MAPT | |
| SCHEMBL10296668 | 0.83 | HTT (0.63) | LMNATP53ALDH1A1MEN1KMT2A | |
| SCHEMBL25872127 | 0.81 | MAPT (0.52) | PKMLMNATP53RXFP1MAPT | |
| SCHEMBL735325 | 0.80 | CYP1A2 (0.51) | PKMLMNATP53RXFP1MAPT | |
| SCHEMBL29154642 | 0.78 | KDM4E (0.60) | LMNATP53RXFP1MAPTALDH1A1 | |
| SCHEMBL8424563 | 0.76 | NPC1 (0.46) | MEN1KMT2AHDAC1HPGD | |
| SCHEMBL7183194 | 0.76 | MAPT (0.55) | LMNATP53RXFP1MAPTALDH1A1 | |
| SCHEMBL16346420 | 0.76 | GAA (0.59) | LMNAMAPTSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL15014130 | 0.76 | TAS1R3 (0.54) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL734053 | 0.74 | TAS1R3 (0.59) | LMNATP53MAPTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3029041-B1 | INHIBITORS OF HUMAN PHOSPHATIDYL-INOSITOL 3-KINASE DELTA | ICOS CORP (US) | 2020-03-04 | — | — | EP | disclosed |