Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SPR | P35270 | 2/20 | 0.33 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.33 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | BRD2 | P25440 | 2/20 | 0.32 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.32 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.32 |
| ▸ | PDE1A | P54750 | 4/20 | 0.32 |
| ▸ | PDE1B | Q01064 | 4/20 | 0.32 |
| ▸ | PDE1C | Q14123 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MPO | P05164 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21783696 | 0.82 | SPR (0.33) | KDM4ESPRPDE1APDE1BPDE1C | |
| SCHEMBL19255291 | 0.81 | HPGD (0.47) | KDM4EALDH1A1ESR1 | |
| SCHEMBL25858587 | 0.73 | CRBN (0.55) | BRD4 | |
| SCHEMBL25864330 | 0.72 | DDB1 (0.56) | — | |
| SCHEMBL21536160 | 0.72 | ADRA2A (0.47) | KDM4EALKBH5FTOCYP1A2PDE1A | |
| SCHEMBL15339576 | 0.69 | KDM4E (0.39) | KDM4ESPRBRD4BRD2BRD3 | |
| SCHEMBL20215514 | 0.69 | ALKBH5 (0.46) | KDM4EALKBH5FTOCYP1A2CYP2A6 | |
| SCHEMBL26067491 | 0.67 | CRBN (0.50) | CYP1A2ALDH1A1 | |
| SCHEMBL23535643 | 0.67 | MAPT (0.41) | SPRBRD4BRD2BRD3PDE1B | |
| SCHEMBL17232698 | 0.67 | RBP4 (0.44) | PDE1APDE1BPDE1CALDH1A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020047208-A1 | INHIBITORS OF (ALPHA-V)(BETA-6) INTEGRIN | MORPHIC THERAPEUTIC, INC. (US) | 2020-03-05 | — | — | WO | disclosed |