Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21783729 | 0.77 | KEAP1 (0.31) | ATM | |
| SCHEMBL2549619 | 0.71 | LMNA (0.60) | LMNAGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL2547997 | 0.70 | GAA (0.61) | LMNAGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL21783632 | 0.68 | CYP3A4 (0.40) | LMNAMEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL27974791 | 0.68 | GAA (0.58) | LMNAGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL28012305 | 0.68 | GAA (0.54) | LMNAGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL303839 | 0.67 | GAA (0.61) | LMNAGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL1829881 | 0.67 | GAA (0.61) | LMNAGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL21784698 | 0.65 | LMNA (0.55) | LMNAGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL2227113 | 0.65 | LMNA (0.96) | LMNAGAAMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020047208-A1 | INHIBITORS OF (ALPHA-V)(BETA-6) INTEGRIN | MORPHIC THERAPEUTIC, INC. (US) | 2020-03-05 | — | — | WO | disclosed |