Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 2/20 | 0.58 |
| ▸ | METAP2 | P50579 | 2/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.58 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8543979 | 0.80 | EIF2AK2 (0.50) | DYRK1AEIF2AK2ALDH1A1HSD17B10CYP1A2 | |
| SCHEMBL29364542 | 0.75 | NOS1 (1.00) | NOS1METAP2DYRK1AALDH1A1HSD17B10 | |
| SCHEMBL5902 | 0.75 | NOS1 (1.00) | NOS1METAP2DYRK1AALDH1A1HSD17B10 | |
| Hydrazine SCHEMBL16698268 | 0.74 | NOS1 (0.89) | NOS1METAP2DYRK1AALDH1A1HSD17B10 | |
| SCHEMBL19781514 | 0.72 | AHR (0.56) | MAPTRAB9ANPC1EGFRKDR | |
| SCHEMBL29898312 | 0.72 | AHR (0.56) | MAPTRAB9ANPC1EGFRKDR | |
| SCHEMBL21786678 | 0.71 | KMT2A (0.47) | NOS1DYRK1AEIF2AK2ALDH1A1HSD17B10 | |
| SCHEMBL29568396 | 0.70 | RAB9A (0.59) | DYRK1AEIF2AK2ALDH1A1HSD17B10CYP1A2 | |
| SCHEMBL20475759 | 0.70 | KDM4E (0.66) | DYRK1AEIF2AK2ALDH1A1HSD17B10CYP1A2 | |
| Hydrochloric Acid SCHEMBL2083483 | 0.70 | ALDH1A1 (0.60) | NOS1METAP2DYRK1AEIF2AK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020046813-A1 | CD73 INHIBITORS | ARCUS BIOSCIENCES, INC. (US) | 2020-03-05 | — | — | WO | disclosed |