Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.33 |
| ▸ | PPM1D | O15297 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21789060 | 0.85 | HSD11B1 (0.31) | TOP2AHSD11B1 | |
| SCHEMBL21788880 | 0.82 | TOP2A (0.40) | TOP2AHSD11B1HSD11B2 | |
| SCHEMBL31106922 | 0.74 | TOP2A (0.32) | TOP2APPM1D | |
| SCHEMBL23389527 | 0.71 | GABRR1 (0.46) | TOP2A | |
| SCHEMBL20919668 | 0.70 | TOP2A (0.35) | TOP2A | |
| SCHEMBL16407751 | 0.70 | TOP2A (0.35) | TOP2A | |
| SCHEMBL25354793 | 0.68 | — | — | |
| SCHEMBL21830040 | 0.68 | CYP4F2 (0.33) | — | |
| SCHEMBL10403720 | 0.67 | — | — | |
| SCHEMBL30782109 | 0.67 | FKBP1A (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020047447-A1 | CARDIAC SARCOMERE INHIBITORS | CYTOKINETICS, INC. (US) | 2020-03-05 | — | — | WO | disclosed |