⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6933789 | 0.78 | — | — | |
| SCHEMBL20416557 | 0.72 | — | — | |
| SCHEMBL23311441 | 0.69 | DDAH1 (0.38) | — | |
| SCHEMBL20442087 | 0.69 | TSHR (0.31) | — | |
| SCHEMBL18012690 | 0.64 | — | — | |
| SCHEMBL22355183 | 0.64 | — | — | |
| SCHEMBL7077041 | 0.63 | — | — | |
| SCHEMBL3588935 | 0.61 | — | — | |
| SCHEMBL21789708 | 0.60 | NOS2 (0.40) | — | |
| SCHEMBL11691790 | 0.58 | TRPA1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11045472-B2 | Quinazoline-pyridine derivatives for the treatment of cancer-related disorders | ARCUS BIOSCIENCES, INC. (US) | 2021-06-29 | — | — | US | disclosed |
| US-20200069689-A1 | QUINAZOLINE-PYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER-RELATED DISORDERS | ARCUS BIOSCIENCES, INC. | 2020-03-05 | — | — | US | disclosed |