Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 5/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 6/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 6/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | HCK | P08631 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.38 |
| ▸ | PRKDC | P78527 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21774261 | 0.81 | ERN1 (0.42) | ERN1HSD17B1HSD17B2PIK3CDABL1 | |
| SCHEMBL21774307 | 0.81 | PGR (0.42) | ERN1PGRHSD17B1HSD17B2PIK3CD | |
| SCHEMBL21793384 | 0.80 | ERN1 (0.48) | ERN1PGRTNFRSF1APTGS1PTGS2 | |
| SCHEMBL21774142 | 0.79 | QPCT (0.41) | ERN1HSD17B1HSD17B2CYP3A4CYP2D6 | |
| SCHEMBL14817182 | 0.79 | HSD17B1 (0.54) | PGRPTGS1PTGS2HSD17B1HSD17B2 | |
| SCHEMBL13438461 | 0.77 | PGR (0.46) | ERN1PGRHSD17B1HSD17B2 | |
| SCHEMBL29828302 | 0.73 | ERN1 (0.46) | ERN1 | |
| SCHEMBL6040627 | 0.72 | ERN1 (0.66) | ERN1PGRTNFRSF1A | |
| SCHEMBL27027638 | 0.72 | PDE3B (0.44) | PGRPTGS1PTGS2HSD17B1HSD17B2 | |
| SCHEMBL18267369 | 0.72 | PGR (0.49) | ERN1PGRTNFRSF1AHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200071312-A1 | BENZIMIDAZOLE COMPOUNDS AND USE THEREOF FOR TREATING ALZHEIMER'S DISEASE OR HUNTINGTON'S DISEASE | NATIONAL HEALTH RES INST (TW) | 2020-03-05 | — | — | US | disclosed |
| WO-2020047360-A1 | BENZIMIDAZOLE COMPOUNDS AND USE THEREOF FOR TREATING ALZHEIMER'S DISEASE OR HUNTINGTON'S DISEASE | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2020-03-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200071312-A1 | BENZIMIDAZOLE COMPOUNDS AND USE THEREOF FOR TREATING ALZHEIMER'S DISEASE OR HUNTINGTON'S DISEASE | GLUL, GLS2, GLS | ERN1 4218/4885PGR 3672/4885TNFRSF1A 4635/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.