Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 1/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.40 |
| ▸ | GPR88 | Q9GZN0 | 2/20 | 0.37 |
| ▸ | NQO2 | P16083 | 1/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | BACE1 | P56817 | 5/20 | 0.35 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2821039 | 0.92 | GPR88 (0.39) | ITGB1ITGA4GPR88NQO2KCNA5 | |
| SCHEMBL2177713 | 0.83 | BACE1 (0.44) | ITGB1ITGA4BACE1CTSKMEN1 | |
| SCHEMBL2167444 | 0.81 | EPHX1 (0.36) | ITGB1ITGA4GPR88NQO2KCNA5 | |
| SCHEMBL2178099 | 0.79 | IDO1 (0.42) | ITGB1ITGA4BACE1CTSKMEN1 | |
| SCHEMBL1710754 | 0.77 | GPR88 (0.39) | GPR88NQO2KCNA5CA1CA2 | |
| SCHEMBL2176308 | 0.76 | L3MBTL1 (0.50) | BACE1 | |
| SCHEMBL2158118 | 0.76 | SIGMAR1 (0.43) | BACE1CTSK | |
| SCHEMBL16031480 | 0.76 | NQO2 (0.51) | NQO2KCNA5CA1CA2MALT1 | |
| SCHEMBL16079975 | 0.76 | POLB (0.45) | GPR88NQO2KCNA5CA1CA2 | |
| SCHEMBL17735443 | 0.76 | POLB (0.45) | GPR88NQO2KCNA5CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2340242-A2 | COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2011-07-06 | — | — | EP | disclosed |