Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | CFTR | P13569 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | MYC | P01106 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21794824 | 0.84 | LMNA (0.38) | KDM4EALDH1A1LMNAKMT2APOLB | |
| SCHEMBL26807421 | 0.75 | BRD4 (0.46) | BRD4NR4A2KDM4EALDH1A1LMNA | |
| SCHEMBL12890135 | 0.65 | ALDH1A1 (0.47) | BRD4KDM4EALDH1A1LMNAMAPT | |
| Dimethyl Phthalate SCHEMBL28376050 | 0.61 | TSHR (0.71) | NR4A2KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL20524639 | 0.60 | PTGS2 (0.51) | BRD4KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL23699698 | 0.60 | MAPT (0.35) | GAAMAPTKMT2AMEN1CA12 | |
| SCHEMBL10103745 | 0.59 | NR4A2 (0.48) | BRD4NR4A2KDM4EALDH1A1LMNA | |
| SCHEMBL10549106 | 0.59 | KDM4E (0.45) | NR4A2KDM4EALDH1A1LMNAGAA | |
| SCHEMBL15536900 | 0.59 | TSHR (0.45) | KDM4EALDH1A1LMNAGAAMAPT | |
| SCHEMBL16694755 | 0.59 | ALDH1A1 (0.60) | BRD4NR4A2KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12128044-B2 | Fused tricyclic compounds and uses thereof in medicine | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2024-10-29 | — | — | US | disclosed |
| CN-111217811-B | Fused tricyclic compounds and application thereof in medicines | 广东东阳光药业股份有限公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-110862390-B | Fused tricyclic compounds and application thereof in medicines | 广东东阳光药业有限公司 | 2023-05-09 | — | — | CN | disclosed |
| US-20210236493-A1 | FUSED TRICYCLIC COMPOUNDS AND USES THEREOF IN MEDICINE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2021-08-05 | — | — | US | disclosed |
| US-20210236493-A1 | FUSED TRICYCLIC COMPOUNDS AND USES THEREOF IN MEDICINE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2021-08-05 | — | — | US | disclosed |
| CN-111217811-A | Fused tricyclic compound and application thereof in medicines | 广东东阳光药业有限公司 | 2020-06-02 | — | — | CN | disclosed |
| CN-111116577-A | Fused tetracyclic compounds and application thereof in medicines | 广东东阳光药业有限公司 | 2020-05-08 | — | — | CN | disclosed |
| CN-110862390-A | Fused tricyclic compound and application thereof in medicines | 广东东阳光药业有限公司 | 2020-03-06 | — | — | CN | disclosed |
| WO-2020043080-A1 | FUSED TRICYCLIC COMPOUNDS AND USES THEREOF IN MEDICINE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2020-03-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12128044-B2 | Fused tricyclic compounds and uses thereof in medicine | SLC10A1, CYP11B1, CYP11B2 | BRD4 2309/4885NR4A2 1224/4885KDM4E 4269/4885 |
| US-20210236493-A1 | FUSED TRICYCLIC COMPOUNDS AND USES THEREOF IN MEDICINE | SLC10A1, CYP11B1, CYP11B2 | BRD4 2309/4885NR4A2 1224/4885KDM4E 4269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.