Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | PRNP | P04156 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | MIF | P14174 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3531804 | 0.80 | TSHR (0.40) | TSHRPRNPMAPK1PPARGHTT | |
| SCHEMBL3920141 | 0.77 | BCKDK (0.39) | TSHRMAPK1HTTNPSR1RXFP1 | |
| SCHEMBL147923 | 0.72 | BCKDK (0.41) | MIFALDH1A1MAPTLMNAMPI | |
| SCHEMBL28707149 | 0.71 | APP (0.37) | TSHRPRNPMAPK1PPARGHTT | |
| SCHEMBL3533860 | 0.69 | ALDH1A1 (0.42) | TSHRHTTALDH1A1KDM4EMAPT | |
| SCHEMBL29768596 | 0.69 | TSHR (0.46) | TSHRPRNPMAPK1PPARGHTT | |
| SCHEMBL8392461 | 0.68 | TSHR (0.49) | TSHRPRNPMAPK1PPARGHTT | |
| SCHEMBL10031374 | 0.67 | HTT (0.51) | TSHRPRNPMAPK1PPARGHTT | |
| SCHEMBL66254 | 0.66 | GPR3 (0.40) | HTTALDH1A1KDM4EMAPTGAA | |
| SCHEMBL18252673 | 0.66 | HTT (0.50) | TSHRPRNPMAPK1PPARGHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112041307-B | Substituted benzothiophene analogs as selective estrogen receptor degrading agents | 伊利诺伊大学评议会 | 2024-02-09 | — | — | CN | disclosed |
| CN-116438177-A | Targeted chimeric compounds, pharmaceutical compositions containing same, and preparation methods and uses thereof | 江苏亚虹医药科技股份有限公司 | 2023-07-14 | — | — | CN | disclosed |
| CN-110177554-B | Combination therapy for the treatment of cancer | G1治疗公司 | 2023-06-02 | — | — | CN | disclosed |
| CN-108699024-B | Benzothienyl selective estrogen receptor down-regulator compounds | 伊利诺伊大学评议会 | 2022-03-11 | — | — | CN | disclosed |
| CN-108495628-B | Benzothienyl selective estrogen receptor down-modulators | 伊利诺伊大学评议会 | 2022-01-11 | — | — | CN | disclosed |
| CN-112041307-A | Substituted benzothiophene analogs as selective estrogen receptor degraders | 伊利诺伊大学评议会 | 2020-12-04 | — | — | CN | disclosed |
| US-10807964-B2 | Benzothiophene-based selective estrogen receptor downregulators | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2020-10-20 | — | — | US | disclosed |
| US-20200079752-A1 | BENZOTHIOPHENE-BASED SELECTIVE ESTROGEN RECEPTOR DOWNREGULATORS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2020-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10807964-B2 | Benzothiophene-based selective estrogen receptor downregulators | ESR1, ESR2, GPER1 | TSHR 287/4885PRNP 4443/4885MAPK1 3793/4885 |
| US-20200079752-A1 | BENZOTHIOPHENE-BASED SELECTIVE ESTROGEN RECEPTOR DOWNREGULATORS | ESR1, ESR2, GPER1 | TSHR 287/4885PRNP 4443/4885MAPK1 3793/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.