SCHEMBL21799299

SCHEMBL21799299

Fc1ccc2c(c1)oc1c(-c3ccccn3)cccc12

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CASP6 P55212 1/20 0.41
JAK2 O60674 1/20 0.41
JAK1 P23458 1/20 0.41
TYK2 P29597 1/20 0.41
JAK3 P52333 1/20 0.41
ALOX5 P09917 2/20 0.40
GRM5 P41594 3/20 0.39
KDM4E B2RXH2 4/20 0.39
HPGD P15428 3/20 0.39
ALDH1A1 P00352 2/20 0.39
MAPT P10636 2/20 0.39
GAA P10253 1/20 0.39
CYP1A2 P05177 2/20 0.39
CYP1A1 P04798 1/20 0.39
CYP1B1 Q16678 1/20 0.39
METAP1 P53582 2/20 0.38
HSD17B10 Q99714 2/20 0.38
METAP2 P50579 1/20 0.38
CBFB Q13951 1/20 0.38
NPC1 O15118 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30688745 1.00 CASP6 (0.41) CASP6JAK2JAK1TYK2JAK3
SCHEMBL29505089 0.86 JAK2 (0.37) CASP6JAK2JAK1TYK2JAK3
SCHEMBL24425927 0.84 CCR1 (0.39) ALOX5PRKDCMAOBCDC25ACDC25C
SCHEMBL483218 0.84 ALOX5 (0.50) JAK2JAK1TYK2JAK3ALOX5
SCHEMBL29496934 0.84 ALOX5 (0.50) JAK2JAK1TYK2JAK3ALOX5
SCHEMBL26083472 0.83 NPC1 (0.51) JAK2JAK1TYK2JAK3ALOX5
SCHEMBL31406850 0.83 AHR (0.51) JAK2JAK1TYK2JAK3ALOX5
SCHEMBL22402331 0.82 JAK2 (0.42) JAK2JAK1TYK2JAK3ALOX5
SCHEMBL483866 0.82 ALOX5 (0.49) JAK2JAK1TYK2JAK3ALOX5
SCHEMBL30531494 0.82 ALOX5 (0.49) JAK2JAK1TYK2JAK3ALOX5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250072279-A1 METAL COMPLEX WITH FLUORINE SUBSTITUTION Beijing Summer Sprout Technology Co., Ltd. (CN) 2025-02-27 US disclosed
US-12167674-B2 Metal complex with fluorine substitution Beijing Summer Sprout Technology Co., Ltd. (CN) 2024-12-10 US disclosed
EP-4098716-B1 METAL COMPLEX WITH FLUORINE SUBSTITUTION BEIJING SUMMER SPROUT TECH CO LTD (CN) 2024-08-21 EP disclosed
CN-117447526-A Containing fluorine-substituted metal complexes 北京夏禾科技有限公司 2024-01-26 CN disclosed
CN-110903321-B Containing fluorine-substituted metal complexes 北京夏禾科技有限公司 2023-12-12 CN disclosed
EP-4098716-A2 METAL COMPLEX WITH FLUORINE SUBSTITUTION Beijing Summer Sprout Technology Co., Ltd. (CN) 2022-12-07 EP disclosed
EP-4098716-A2 METAL COMPLEX WITH FLUORINE SUBSTITUTION Beijing Summer Sprout Technology Co., Ltd. (CN) 2022-12-07 EP disclosed
US-20220181560-A1 PHOSPHORESCENT ORGANOMETALLIC COMPLEX AND DEVICE THEREOF Beijing Summer Sprout Technology Co., Ltd. (CN) 2022-06-09 US disclosed
EP-3623443-B1 METAL COMPLEX WITH FLUORINE SUBSTITUTION BEIJING SUMMER SPROUT TECH CO LTD (CN) 2022-05-18 EP disclosed
EP-3623443-B1 METAL COMPLEX WITH FLUORINE SUBSTITUTION BEIJING SUMMER SPROUT TECH CO LTD (CN) 2022-05-18 EP disclosed
CN-110903321-A Metal complexes containing fluorine substitution 北京夏禾科技有限公司 2020-03-24 CN disclosed
US-20200091442-A1 METAL COMPLEX WITH FLUORINE SUBSTITUTION Beijing Summer Sprout Technology Co., Ltd. (CN) 2020-03-19 US disclosed
EP-3623443-A1 METAL COMPLEX WITH FLUORINE SUBSTITUTION Beijing Summer Sprout Technology Co., Ltd. (CN) 2020-03-18 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250072279-A1 METAL COMPLEX WITH FLUORINE SUBSTITUTION AFF4, AFF2, AFF1 CASP6 2043/4885JAK2 2971/4885JAK1 4359/4885
US-12167674-B2 Metal complex with fluorine substitution AFF4, AFF2, AFF1 CASP6 2043/4885JAK2 2971/4885JAK1 4359/4885
US-20200091442-A1 METAL COMPLEX WITH FLUORINE SUBSTITUTION AFF4, AFF2, AFF1 CASP6 2043/4885JAK2 2971/4885JAK1 4359/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.