Choline

Choline

SCHEMBL4199945

C[N+](C)(C)CCO.NC=O.[Cl-]

nearest known ligand 0.68

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2

The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.68
SLC5A7 Q9GZV3 1/20 0.68
LMNA P02545 3/20 0.60
MEN1 O00255 1/20 0.60
KMT2A Q03164 1/20 0.60
CHRM5 P08912 3/20 0.38
CHRM1 P11229 3/20 0.38
CHRM3 P20309 3/20 0.38
CHRM2 P08172 2/20 0.38
CHRM4 P08173 2/20 0.38
BLM P54132 3/20 0.38
APEX1 P27695 2/20 0.35
NPSR1 Q6W5P4 1/20 0.35
TSHR P16473 2/20 0.34
BBOX1 O75936 2/20 0.34
POLB P06746 1/20 0.34
ATM Q13315 1/20 0.34
MAPT P10636 1/20 0.34
HTR1A P08908 1/20 0.34
CHRNB2 P17787 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Choline SCHEMBL21800980 0.89 CYP3A4 (0.77) CYP3A4SLC5A7LMNAMEN1KMT2A
Choline SCHEMBL992915 0.86 MEN1 (0.71) CYP3A4SLC5A7LMNAMEN1KMT2A
Choline SCHEMBL2469440 0.83 MEN1 (0.67) CYP3A4SLC5A7LMNAMEN1KMT2A
Choline SCHEMBL29118960 0.83 MEN1 (0.77) CYP3A4SLC5A7LMNAMEN1KMT2A
Choline SCHEMBL28715885 0.83 CYP3A4 (0.87) CYP3A4SLC5A7LMNAMEN1KMT2A
Choline SCHEMBL14957 0.83
Choline SCHEMBL2459999 0.83 CYP3A4 (1.00) CYP3A4SLC5A7LMNAMEN1KMT2A
Choline SCHEMBL1330530 0.83
Choline SCHEMBL1332010 0.83
Choline SCHEMBL9391204 0.83 CYP3A4 (1.00) CYP3A4SLC5A7LMNAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115806465-A Separation method of mixed dichlorobenzene 中国石油化工股份有限公司 2023-03-17 CN claimed
WO-2017175101-A1 SYNTHESIS OF COPPER PHTHALOCYANINE USING DEEP EUTECTIC SOLVENT SHANKARLING G S (IN) 2017-10-12 WO claimed
CN-115806465-A Separation method of mixed dichlorobenzene 中国石油化工股份有限公司 2023-03-17 CN disclosed
WO-2017175101-A1 SYNTHESIS OF COPPER PHTHALOCYANINE USING DEEP EUTECTIC SOLVENT SHANKARLING G S (IN) 2017-10-12 WO disclosed
EP-2961268-A1 SAMPLE FIXATION AND STABILISATION Goldsborough, Andrew Simon (FR) 2016-01-06 EP disclosed
WO-2014131906-A1 SAMPLE FIXATION AND STABILISATION GOLDSBOROUGH ANDREW SIMON (FR) 2014-09-04 WO disclosed
WO-2012145522-A2 DEEP EUTECTIC SOLVENT SYSTEMS AND METHODS GEORGIA TECH RESEARCH CORPORATION (US) 2012-10-26 WO disclosed
US-8247198-B2 Enzymatic processing in deep eutectic solvents FRIEDRICH SRIENC (US) 2012-08-21 US disclosed
US-20090117628-A1 Enzymatic processing in deep eutectic solvents SRIENC, FRIEDRICH 2009-05-07 US disclosed