SCHEMBL21802017

SCHEMBL21802017

O=C1c2ccccc2C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1

nearest known ligand 0.76

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
HTR7 P34969 8/20 0.76
HTR1A P08908 9/20 0.73
DRD2 P14416 6/20 0.73
HTR2A P28223 5/20 0.73
HTR6 P50406 3/20 0.73
DRD3 P35462 4/20 0.72
DRD5 P21918 3/20 0.72
ADRA1D P25100 1/20 0.69
ADRA1A P35348 1/20 0.69
ADRA1B P35368 1/20 0.69
DRD1 P21728 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10836050 0.98 HTR7 (0.72) HTR7HTR1ADRD2HTR2AHTR6
SCHEMBL9369051 0.86 DRD2 (0.63) HTR7HTR1ADRD2HTR2AHTR6
SCHEMBL10517807 0.84 DRD2 (0.64) HTR7HTR1ADRD2HTR2AHTR6
SCHEMBL21802146 0.84 HTR1A (0.74) HTR7HTR1ADRD2HTR2AHTR6
SCHEMBL11630613 0.84 HTR7 (0.73) HTR7HTR1ADRD2HTR2AHTR6
SCHEMBL11817633 0.84 HTR7 (0.62) HTR7HTR1ADRD2HTR2AHTR6
Hydrochloric Acid SCHEMBL10518350 0.84 DRD2 (0.63) HTR7HTR1ADRD2HTR2AHTR6
SCHEMBL11465528 0.84 SIGMAR1 (0.76) HTR7HTR1ADRD2HTR2ADRD3
SCHEMBL6865196 0.83 HTR7 (0.87) HTR7HTR1ADRD2HTR2AHTR6
SCHEMBL10782032 0.83 HTR7 (0.80) HTR7HTR1ADRD2HTR2AHTR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12319659-B2 Selective ligand for dopamine D3 receptor, preparation method therefor, and pharmaceutical application thereof SHENZHEN LINGLAN BIO-PHARMACEUTICAL TECHNOLOGY CO., LTD (CN) 2025-06-03 US disclosed
US-20200087264-A1 NOVEL SELECTIVE LIGAND FOR DOPAMINE D3 RECEPTOR, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL APPLICATION THEREOF Shenzhen City Linglan Bio-Pharmaceutical Technology Co., Ltd (CN) 2020-03-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200087264-A1 NOVEL SELECTIVE LIGAND FOR DOPAMINE D3 RECEPTOR, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL APPLICATION THEREOF DRD3, DRD2, PRLHR HTR7 144/4885HTR1A 112/4885DRD2 2/4885
US-12319659-B2 Selective ligand for dopamine D3 receptor, preparation method therefor, and pharmaceutical application thereof DRD3, DRD2, PRLHR HTR7 130/4885HTR1A 125/4885DRD2 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.