SCHEMBL21802153

SCHEMBL21802153

O=C(NCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)Nc1cnc2ccccc2c1

nearest known ligand 0.62

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 1/20 0.62
DRD2 P14416 13/20 0.61
DRD3 P35462 12/20 0.61
ADRA1A P35348 5/20 0.61
HTR2A P28223 4/20 0.59
HTR1A P08908 3/20 0.59
HTR2C P28335 2/20 0.59
HRH4 Q9H3N8 1/20 0.55
TP53 P04637 1/20 0.54
MAPT P10636 1/20 0.54
DRD5 P21918 1/20 0.54
HTR7 P34969 3/20 0.53
HTR6 P50406 2/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21802147 0.89 HTR7 (0.66) DRD2DRD3ADRA1AHTR2AHTR1A
SCHEMBL21802157 0.87 LMNA (0.53) TRPV1DRD2DRD3ADRA1AHTR2A
SCHEMBL21802020 0.84 DRD3 (0.55) DRD2DRD3ADRA1AHTR2AHTR1A
SCHEMBL21802141 0.84 HTR7 (0.65) DRD2DRD3ADRA1AHTR2AHTR1A
SCHEMBL21802095 0.82 LMNA (0.67) DRD2DRD3ADRA1AHTR2AHTR1A
SCHEMBL21802149 0.82 DRD2 (0.60) DRD2DRD3ADRA1AHTR2AHTR1A
SCHEMBL21802148 0.81 DRD3 (0.59) DRD2DRD3ADRA1AHTR2AHTR1A
SCHEMBL21802154 0.81 DRD2 (0.67) DRD2DRD3ADRA1AHTR2AHTR1A
SCHEMBL21802018 0.80 LMNA (0.59) DRD2DRD3ADRA1AHTR2AHTR1A
SCHEMBL21802155 0.80 DRD2 (0.75) DRD2DRD3ADRA1AHTR2AHTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12319659-B2 Selective ligand for dopamine D3 receptor, preparation method therefor, and pharmaceutical application thereof SHENZHEN LINGLAN BIO-PHARMACEUTICAL TECHNOLOGY CO., LTD (CN) 2025-06-03 US claimed
US-20200087264-A1 NOVEL SELECTIVE LIGAND FOR DOPAMINE D3 RECEPTOR, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL APPLICATION THEREOF Shenzhen City Linglan Bio-Pharmaceutical Technology Co., Ltd (CN) 2020-03-19 US claimed
US-12319659-B2 Selective ligand for dopamine D3 receptor, preparation method therefor, and pharmaceutical application thereof SHENZHEN LINGLAN BIO-PHARMACEUTICAL TECHNOLOGY CO., LTD (CN) 2025-06-03 US disclosed
US-20200087264-A1 NOVEL SELECTIVE LIGAND FOR DOPAMINE D3 RECEPTOR, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL APPLICATION THEREOF Shenzhen City Linglan Bio-Pharmaceutical Technology Co., Ltd (CN) 2020-03-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200087264-A1 NOVEL SELECTIVE LIGAND FOR DOPAMINE D3 RECEPTOR, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL APPLICATION THEREOF DRD3, DRD2, PRLHR TRPV1 891/4885DRD2 2/4885DRD3 1/4885
US-12319659-B2 Selective ligand for dopamine D3 receptor, preparation method therefor, and pharmaceutical application thereof DRD3, DRD2, PRLHR TRPV1 794/4885DRD2 2/4885DRD3 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.