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SCHEMBL2180307

SCHEMBL2180307

COc1cccc(NC(=S)Nc2ccc(-c3ccc4c(c3)C(=O)N([C@H](C(=O)O)C(C)C)C4)cc2)c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 2/20 0.52
▸ TP53 P04637 1/20 0.52
▸ MEN1 O00255 1/20 0.45
▸ MAPT P10636 1/20 0.45
▸ IDO1 P14902 1/20 0.45
▸ KMT2A Q03164 1/20 0.45
▸ KDR P35968 1/20 0.44
▸ DGAT1 O75907 2/20 0.44
▸ PPIA P62937 1/20 0.42
▸ L3MBTL1 Q9Y468 1/20 0.42
▸ NPC1 O15118 1/20 0.41
▸ CYP2C19 P33261 1/20 0.41
▸ GAA P10253 1/20 0.41
▸ ATM Q13315 1/20 0.41
▸ MTNR1B P49286 1/20 0.41
▸ TRPV1 Q8NER1 1/20 0.41
▸ P2RX2 Q9UBL9 1/20 0.40
▸ ALDH1A1 P00352 1/20 0.40
▸ HTT P42858 1/20 0.40
▸ SDCBP O00560 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2180314 1.00 LMNA (0.52) LMNATP53MEN1MAPTIDO1
SCHEMBL2177510 0.93 LMNA (0.52) LMNATP53MEN1MAPTIDO1
SCHEMBL2177019 0.93 LMNA (0.52) LMNATP53MEN1MAPTIDO1
SCHEMBL2177471 0.93 TP53 (0.53) LMNATP53MEN1MAPTKMT2A
SCHEMBL2178942 0.93 TP53 (0.53) LMNATP53MEN1MAPTKMT2A
SCHEMBL2177961 0.92 LMNA (0.58) LMNATP53MEN1MAPTKMT2A
SCHEMBL2179308 0.92 LMNA (0.58) LMNATP53MEN1MAPTKMT2A
SCHEMBL2179260 0.88 PPIA (0.46) LMNATP53MAPTKDRDGAT1
SCHEMBL2181156 0.88 PPIA (0.46) LMNATP53MAPTKDRDGAT1
SCHEMBL2179028 0.88 SDCBP (0.45) LMNATP53MEN1KMT2AKDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8748426-B2 Inhibitors of diacylglycerol acyl transferase Piramal Enterprises Limited (IN) 2014-06-10 — — US claimed
US-20120289505-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE Piramal Enterprises Limited (IN) 2012-11-15 — — US claimed
EP-2519500-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE Piramal Healthcare Ltd. (IN) 2012-11-07 — — EP claimed
WO-2011080718-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE PIRAMAL LIFE SCIENCES LIMITED (IN) 2011-07-07 — — WO claimed
US-8748426-B2 Inhibitors of diacylglycerol acyl transferase Piramal Enterprises Limited (IN) 2014-06-10 — — US disclosed
US-20120289505-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE Piramal Enterprises Limited (IN) 2012-11-15 — — US disclosed
EP-2519500-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE Piramal Healthcare Ltd. (IN) 2012-11-07 — — EP disclosed
WO-2011080718-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE PIRAMAL LIFE SCIENCES LIMITED (IN) 2011-07-07 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120289505-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE DGAT1, DGAT2, LCAT LMNA 2193/4885TP53 2093/4885MEN1 3071/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.