SCHEMBL21805907

SCHEMBL21805907

COc1ncc(C23CCC(C=O)(CC2)CC3)cc1C

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21805122 0.78 HSD11B1 (0.36)
SCHEMBL21805081 0.77 TUBB1 (0.32)
SCHEMBL21805983 0.77 CCR2 (0.31)
SCHEMBL20500560 0.74 PDE4A (0.36)
SCHEMBL29404742 0.71 TUBB1 (0.31)
SCHEMBL21806070 0.70 LMNA (0.34)
SCHEMBL2484983 0.69 MTOR (0.39)
SCHEMBL22083808 0.67 ALDH1A1 (0.42)
SCHEMBL22347234 0.67 UHRF1 (0.37)
SCHEMBL29405386 0.67 TUBB1 (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250289821-A1 FARNESOID X RECEPTOR AGONISTS AND USES THEREOF ELI LILLY AND COMPANY 2025-09-18 US disclosed
EP-3852748-B1 FARNESOID X RECEPTOR AGONISTS AND USES THEREOF LILLY CO ELI (US) 2025-09-03 EP disclosed
EP-4596543-A2 FARNESOID X RECEPTOR AGONISTS AND USES THEREOF Organovo, Inc. (US) 2025-08-06 EP disclosed
US-20230382913-A1 FARNESOID X RECEPTOR AGONISTS AND USES THEREOF ORGANOVO, INC. 2023-11-30 US disclosed
US-20230382913-A1 FARNESOID X RECEPTOR AGONISTS AND USES THEREOF ORGANOVO, INC. 2023-11-30 US disclosed
US-20230382913-A1 FARNESOID X RECEPTOR AGONISTS AND USES THEREOF ORGANOVO, INC. 2023-11-30 US disclosed
US-11773094-B2 Farnesoid X receptor agonists and uses thereof ORGANOVO, INC. (US) 2023-10-03 US disclosed
US-11773094-B2 Farnesoid X receptor agonists and uses thereof ORGANOVO, INC. (US) 2023-10-03 US disclosed
US-11773094-B2 Farnesoid X receptor agonists and uses thereof ORGANOVO, INC. (US) 2023-10-03 US disclosed
US-20220054469-A1 FARNESOID X RECEPTOR AGONISTS AND USES THEREOF METACRINE, INC. 2022-02-24 US disclosed
US-11084817-B2 Farnesoid X receptor agonists and uses thereof METACRINE, INC. (US) 2021-08-10 US disclosed
EP-3852737-A1 FARNESOID X RECEPTOR AGONISTS AND USES THEREOF Metacrine, Inc. (US) 2021-07-28 EP disclosed
EP-3852736-A1 FARNESOID X RECEPTOR AGONISTS AND USES THEREOF Metacrine, Inc. (US) 2021-07-28 EP disclosed
US-20200102308-A1 FARNESOID X RECEPTOR AGONISTS AND USES THEREOF ELI LILLY AND COMPANY 2020-04-02 US disclosed
US-20200102308-A1 FARNESOID X RECEPTOR AGONISTS AND USES THEREOF ELI LILLY AND COMPANY 2020-04-02 US disclosed
WO-2020061112-A1 FARNESOID X RECEPTOR AGONISTS AND USES THEREOF METACRINE, INC. (US) 2020-03-26 WO disclosed
WO-2020061118-A1 FARNESOID X RECEPTOR AGONISTS AND USES THEREOF METACRINE, INC. (US) 2020-03-26 WO disclosed
WO-2020061112-A1 FARNESOID X RECEPTOR AGONISTS AND USES THEREOF METACRINE, INC. (US) 2020-03-26 WO disclosed
WO-2020061117-A1 FARNESOID X RECEPTOR AGONISTS AND USES THEREOF METACRINE, INC. (US) 2020-03-26 WO disclosed
WO-2020061116-A1 FARNESOID X RECEPTOR AGONISTS AND USES THEREOF METACRINE, INC. (US) 2020-03-26 WO disclosed