Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2182686 | 0.94 | POLB (0.47) | POLBMAPK1ALDH1A1RXFP1L3MBTL1 | |
| SCHEMBL2182767 | 0.89 | POLB (0.43) | POLBMAPK1ALDH1A1KMT2AMEN1 | |
| SCHEMBL2182836 | 0.86 | POLB (0.43) | POLBMAPK1ALDH1A1RXFP1L3MBTL1 | |
| SCHEMBL2179600 | 0.84 | ALDH1A1 (0.44) | POLBMAPK1ALDH1A1CYP2C19CYP3A4 | |
| SCHEMBL2182443 | 0.83 | LMNA (0.43) | POLBALDH1A1KMT2AMEN1HSD17B10 | |
| SCHEMBL2182023 | 0.81 | POLB (0.53) | POLBMAPK1ALDH1A1ALOX15HSD17B10 | |
| SCHEMBL2182462 | 0.81 | ALDH1A1 (0.38) | POLBALDH1A1CYP2C19CYP2D6KMT2A | |
| SCHEMBL2182199 | 0.80 | MAPK1 (0.45) | MAPK1ALDH1A1CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL2181567 | 0.80 | USP2 (0.47) | POLBMAPK1ALDH1A1CYP2C19CYP3A4 | |
| SCHEMBL2182956 | 0.80 | CYP2C19 (0.40) | POLBALDH1A1L3MBTL1CYP2C19CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110166144-A1 | Pyrimidotriazinediones and Pyrimidopyrimidinediones and Methods of Using the Same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166144-A1 | Pyrimidotriazinediones and Pyrimidopyrimidinediones and Methods of Using the Same | DPYD, TYMP, DHFR | POLB 312/4885MAPK1 3843/4885ALDH1A1 245/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.