SCHEMBL21811819

SCHEMBL21811819

O=CCc1c(O)ccc(Cl)c1O

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.37
MAPK1 P28482 2/20 0.37
DPP4 P27487 1/20 0.36
ERN1 O75460 2/20 0.34
PIK3CA P42336 1/20 0.33
MEN1 O00255 3/20 0.32
LMNA P02545 3/20 0.32
MAPT P10636 3/20 0.32
KMT2A Q03164 3/20 0.32
TSHR P16473 3/20 0.32
HSD17B10 Q99714 3/20 0.32
HPGD P15428 2/20 0.32
HTT P42858 2/20 0.32
NPC1 O15118 2/20 0.32
POLB P06746 2/20 0.32
ALOX15 P16050 2/20 0.32
USP2 O75604 1/20 0.32
EGFR P00533 1/20 0.32
ESR1 P03372 1/20 0.32
ERBB2 P04626 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21812009 0.88 DPP4 (0.39) CYP3A4MAPK1DPP4ERN1MEN1
SCHEMBL21811824 0.81 ERN1 (0.36) CYP3A4MAPK1DPP4ERN1PIK3CA
SCHEMBL21811818 0.81 DPP4 (0.34) CYP3A4MAPK1DPP4ERN1MEN1
SCHEMBL11408330 0.78 CYP3A4 (0.32) CYP3A4MAPK1ERN1ALOX15IGF1R
SCHEMBL21822850 0.78 HTR3E (0.36) DPP4MEN1LMNAMAPTKMT2A
SCHEMBL10012584 0.76 HSD17B10 (0.48) CYP3A4MAPK1DPP4PIK3CAMEN1
SCHEMBL4966941 0.76 TRPA1 (0.35) MEN1LMNAMAPTKMT2AHPGD
SCHEMBL1238697 0.76 TSHR (0.45) CYP3A4MAPK1ERN1MEN1LMNA
SCHEMBL17377707 0.74 GABRA1 (0.43) MEN1LMNAMAPTKMT2ATSHR
SCHEMBL31187328 0.74 HSD17B10 (0.34) ERN1MEN1MAPTKMT2AHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3894004-A1 CHROMAN-4-ONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION F. Hoffmann-La Roche AG (CH) 2021-10-20 EP disclosed
EP-3860984-A1 FLAVONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE F. Hoffmann-La Roche AG (CH) 2021-08-11 EP disclosed
EP-3849966-A1 FLAVONE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE F. Hoffmann-La Roche AG (CH) 2021-07-21 EP disclosed
WO-2020120642-A1 CHROMAN-4-ONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION F. HOFFMANN-LA ROCHE AG (CH) 2020-06-18 WO disclosed
WO-2020070088-A1 FLAVONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE F. HOFFMANN-LA ROCHE AG (CH) 2020-04-09 WO disclosed
WO-2020053249-A1 FLAVONE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE F. HOFFMANN-LA ROCHE AG (CH) 2020-03-19 WO disclosed