Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 6/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21812556 | 0.83 | HDAC3 (0.48) | NAMPTROCK2KCNH2GRM4ROCK1 | |
| SCHEMBL21834597 | 0.76 | ALDH1A1 (0.49) | ROCK2MAPK1ROCK1ALDH1A1RAB9A | |
| SCHEMBL2342868 | 0.73 | CNR2 (0.62) | MAPK1ALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL25180665 | 0.72 | RAB9A (0.54) | NAMPTMAPK1ALDH1A1RAB9A | |
| SCHEMBL22501830 | 0.69 | ROCK2 (0.59) | ROCK2ROCK1 | |
| SCHEMBL19259693 | 0.68 | ROCK2 (0.41) | ROCK2MAPK1ALDH1A1RAB9A | |
| SCHEMBL29999682 | 0.68 | NPC1 (0.36) | ALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL29859845 | 0.68 | KCNH2 (0.48) | KCNH2GRM4MAPK1ALDH1A1RAB9A | |
| SCHEMBL17293023 | 0.68 | NAMPT (0.51) | NAMPTROCK2 | |
| SCHEMBL18215350 | 0.68 | MAPK1 (0.56) | MAPK1ALDH1A1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020064175-A1 | INDANE DERIVATIVES FOR USE IN THE TREATMENT OF BACTERIAL INFECTION | ANTABIO SAS (FR) | 2020-04-02 | — | — | WO | disclosed |
| EP-3628672-A1 | INDANE DERIVATIVES FOR USE IN THE TREATMENT OF BACTERIAL INFECTION | Antabio SAS (FR) | 2020-04-01 | — | — | EP | disclosed |