Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE2 | O96020 | 8/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 8/20 | 0.37 |
| ▸ | CDK2 | P24941 | 8/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 5/20 | 0.35 |
| ▸ | CDK1 | P06493 | 5/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.35 |
| ▸ | CCNB3 | Q8WWL7 | 5/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | CCND2 | P30279 | 1/20 | 0.34 |
| ▸ | CCND3 | P30281 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 4/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21815219 | 0.94 | GRM4 (0.36) | CCNE2CCNE1CDK2CCNB2CDK1 | |
| SCHEMBL21815215 | 0.89 | CCNE2 (0.36) | CCNE2CCNE1CDK2CCNB2CDK1 | |
| SCHEMBL21804283 | 0.83 | TSHR (0.47) | ALDH1A1TSHRL3MBTL1TDP1TP53 | |
| SCHEMBL21804494 | 0.76 | TSHR (0.49) | ALDH1A1HTTTSHR | |
| SCHEMBL21815230 | 0.73 | RARB (0.43) | ALDH1A1HTTSMN1; SMN2TSHRMAPK1 | |
| SCHEMBL21805554 | 0.72 | TSHR (0.47) | ALDH1A1HTTTSHRL3MBTL1TDP1 | |
| SCHEMBL20523594 | 0.72 | ALDH1A1 (0.33) | CCNE2CCNE1CDK2ALDH1A1MAPK1 | |
| SCHEMBL7257515 | 0.70 | ALDH1A1 (0.55) | ALDH1A1TSHRL3MBTL1TDP1TP53 | |
| SCHEMBL28026639 | 0.68 | LMNA (0.55) | ALDH1A1SMN1; SMN2TSHRL3MBTL1TDP1 | |
| SCHEMBL11552370 | 0.68 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3856188-A1 | AMINOPYRIMIDINE COMPOUND | Cardurion Pharmaceuticals, LLC (US) | 2021-08-04 | — | — | EP | disclosed |
| WO-2020068854-A1 | AMINOPYRIMIDINE COMPOUND | CARDURION PHARMACEUTICALS, LLC (US) | 2020-04-02 | — | — | WO | disclosed |