⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL485615 | 0.74 | MGLL (0.44) | — | |
| SCHEMBL5531964 | 0.73 | HPGD (0.38) | — | |
| SCHEMBL18881098 | 0.72 | CYP1B1 (0.34) | — | |
| SCHEMBL5495765 | 0.71 | CYP1B1 (0.35) | — | |
| SCHEMBL16484921 | 0.71 | CYP1B1 (0.35) | — | |
| SCHEMBL20365061 | 0.68 | CYP1B1 (0.44) | — | |
| SCHEMBL4761414 | 0.67 | MGLL (0.46) | — | |
| SCHEMBL28952214 | 0.67 | MGLL (0.37) | — | |
| SCHEMBL1707544 | 0.67 | MGLL (0.41) | — | |
| SCHEMBL10147918 | 0.66 | MGLL (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230322925-A1 | PHOSPHOLIPID ETHER (PLE) CAR T CELL TUMOR TARGETING (CTCT) AGENTS | SEATTLE CHILDREN’S HOSPITAL DBA SEATTLE CHILDREN’S RES INSTITUTE (US) | 2023-10-12 | — | — | US | disclosed |
| US-11649288-B2 | Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents | SEATTLE CHILDREN'S HOSPITAL (US) | 2023-05-16 | — | — | US | disclosed |
| US-20200087399-A1 | PHOSPHOLIPID ETHER (PLE) CAR T CELL TUMOR TARGETING (CTCT) AGENTS | Seattle Children's Hospital (dba Seattle Children's Research Institute) | 2020-03-19 | — | — | US | disclosed |