Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | FAAH | O00519 | 2/20 | 0.31 |
| ▸ | GMNN | O75496 | 1/20 | 0.31 |
| ▸ | THPO | P40225 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.31 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | XBP1 | P17861 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL485615 | 0.82 | MGLL (0.44) | HPGDCYP1B1MGLLALDH1A1LMNA | |
| SCHEMBL16484921 | 0.77 | CYP1B1 (0.35) | HPGDCYP1B1MGLLALDH1A1LMNA | |
| SCHEMBL5495765 | 0.77 | CYP1B1 (0.35) | HPGDCYP1B1MGLLALDH1A1LMNA | |
| SCHEMBL10389604 | 0.75 | LMNA (0.39) | HPGDCYP1B1MGLLALDH1A1LMNA | |
| SCHEMBL20365061 | 0.74 | CYP1B1 (0.44) | HPGDCYP1B1MGLLALDH1A1LMNA | |
| SCHEMBL1707544 | 0.73 | MGLL (0.41) | HPGDCYP1B1MGLLALDH1A1LMNA | |
| SCHEMBL21820802 | 0.73 | — | — | |
| SCHEMBL4761414 | 0.73 | MGLL (0.46) | HPGDCYP1B1MGLLALDH1A1LMNA | |
| SCHEMBL10147918 | 0.72 | MGLL (0.38) | HPGDCYP1B1MGLLALDH1A1LMNA | |
| SCHEMBL1275809 | 0.72 | CYP1B1 (0.45) | HPGDCYP1B1MGLLALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111110859-A | Maytansine polypeptide conjugate and preparation method and application thereof | 烟台药物研究所 | 2020-05-08 | — | — | CN | claimed |
| US-7153977-B2 | Ligands and methods for preparing same | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2006-12-26 | — | — | US | claimed |
| US-20040132981-A1 | Novel ligands and methods for preparing same | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2004-07-08 | — | — | US | claimed |
| EP-1289561-A2 | LIGAND CONJUGATES AND METHODS FOR PREPARING SAME | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2003-03-12 | — | — | EP | claimed |
| US-20010051348-A1 | Novel ligands and methods for preparing same | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2001-12-13 | — | — | US | claimed |
| WO-2001054731-A2 | LIGAND CONJUGATES AND METHODS FOR PREPARING SAME | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2001-08-02 | — | — | WO | claimed |
| CN-111110859-A | Maytansine polypeptide conjugate and preparation method and application thereof | 烟台药物研究所 | 2020-05-08 | — | — | CN | disclosed |
| US-20070027310-A1 | Novel ligands and methods for preparing same | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2007-02-01 | — | — | US | disclosed |
| US-7153977-B2 | Ligands and methods for preparing same | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2006-12-26 | — | — | US | disclosed |
| US-20040132981-A1 | Novel ligands and methods for preparing same | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2004-07-08 | — | — | US | disclosed |
| EP-1289561-A2 | LIGAND CONJUGATES AND METHODS FOR PREPARING SAME | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2003-03-12 | — | — | EP | disclosed |
| US-20010051348-A1 | Novel ligands and methods for preparing same | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2001-12-13 | — | — | US | disclosed |
| WO-2001054731-A2 | LIGAND CONJUGATES AND METHODS FOR PREPARING SAME | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2001-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010051348-A1 | Novel ligands and methods for preparing same | ADGRF1, ADGRE5, TACR2 | HPGD 2251/4885CYP1B1 2298/4885MGLL 2561/4885 |
| US-20070027310-A1 | Novel ligands and methods for preparing same | ADGRF1, ADGRE5, TACR2 | HPGD 2251/4885CYP1B1 2298/4885MGLL 2561/4885 |
| US-20040132981-A1 | Novel ligands and methods for preparing same | ADGRF1, ADGRE5, TACR2 | HPGD 2251/4885CYP1B1 2298/4885MGLL 2561/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.