Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.35 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.35 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22952937 | 0.77 | NPC1 (0.51) | CYP3A4NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL28924711 | 0.76 | ELANE (0.56) | CYP3A4PDE10AKDM4EALDH1A1ELANE | |
| SCHEMBL950607 | 0.74 | PBRM1 (0.38) | CYP3A4NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL950650 | 0.72 | KDM4E (0.31) | CYP3A4PDE10AKDM4E | |
| SCHEMBL950689 | 0.71 | TUBB4A (0.34) | CYP3A4PDE10AKDM4EALDH1A1ELANE | |
| SCHEMBL7191472 | 0.71 | IKBKB (0.42) | NPC1RAB9AKDM4EALDH1A1ELANE | |
| SCHEMBL952855 | 0.70 | MAT2A (0.39) | CYP3A4PDE10AKDM4EALDH1A1MAPT | |
| SCHEMBL950123 | 0.70 | CYP17A1 (0.37) | CYP3A4PDE10AKDM4EALDH1A1ELANE | |
| SCHEMBL951593 | 0.70 | NPSR1 (0.34) | CYP3A4PDE10AALDH1A1ELANEMAPT | |
| SCHEMBL951145 | 0.70 | MAT2A (0.39) | CYP3A4PDE10AKDM4EALDH1A1ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3632911-B1 | METHOD FOR PREPARING ISOXAZINONE COMPOUND AND APPLICATION THEREOF | ZHEJIANG ZHUJI UNITED CHEMICALS CO LTD (CN) | 2023-08-09 | — | — | EP | disclosed |
| US-11299499-B2 | Preparation method and application of isoxazinone compounds | Zhejiang Zhuji United Chemicals Co., Ltd. (CN) | 2022-04-12 | — | — | US | disclosed |
| CN-107033135-B | Method for preparing isooxazinone compound and application thereof | 浙江省诸暨合力化学对外贸易有限公司 | 2020-09-11 | — | — | CN | disclosed |
| US-20200109152-A1 | PREPARATION METHOD AND APPLICATION OF ISOXAZINONE COMPOUNDS | Zhejiang Zhuji United Chemicals Co., Ltd. (CN) | 2020-04-09 | — | — | US | disclosed |
| EP-3632911-A1 | METHOD FOR PREPARING ISOXAZINONE COMPOUND AND APPLICATION THEREOF | Zhejiang Zhuji United Chemicals Co., Ltd (CN) | 2020-04-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11299499-B2 | Preparation method and application of isoxazinone compounds | NISCH, SI, DAO | CSF1R 4874/4885CYP3A4 251/4885PDE10A 1177/4885 |
| US-20200109152-A1 | PREPARATION METHOD AND APPLICATION OF ISOXAZINONE COMPOUNDS | NISCH, SI, DAO | CSF1R 4874/4885CYP3A4 251/4885PDE10A 1177/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.