Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.38 |
| ▸ | S1PR2 | O95136 | 3/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.38 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21828359 | 1.00 | ALDH1A1 (0.42) | ALDH1A1TP53TSHRALOX15KDM4E | |
| SCHEMBL26731555 | 1.00 | ALDH1A1 (0.42) | ALDH1A1TP53TSHRALOX15KDM4E | |
| SCHEMBL25644246 | 0.85 | TSHR (0.45) | ALDH1A1TSHRMEN1KMT2ASMPD1 | |
| SCHEMBL24588895 | 0.83 | NAAA (0.43) | TP53ALOX15 | |
| SCHEMBL29774929 | 0.83 | NAAA (0.43) | TP53ALOX15 | |
| SCHEMBL24573296 | 0.83 | LPAR2 (0.39) | ALDH1A1TP53ALOX15KDM4ELMNA | |
| SCHEMBL31578697 | 0.83 | LMNA (0.52) | ALDH1A1TSHRLMNAHSD17B10MEN1 | |
| SCHEMBL31647994 | 0.83 | LMNA (0.52) | ALDH1A1TSHRLMNAHSD17B10MEN1 | |
| SCHEMBL31252980 | 0.81 | LMNA (0.48) | ALDH1A1TSHRLMNAHSD17B10MEN1 | |
| SCHEMBL16013242 | 0.81 | LMNA (0.48) | ALDH1A1TSHRLMNAHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113039174-B | Ionizable amine lipids | 英特利亚治疗股份有限公司 | 2023-11-17 | — | — | CN | disclosed |
| US-20220009878-A1 | IONIZABLE AMINE LIPIDS | INTELLIA THERAPEUTICS, INC. | 2022-01-13 | — | — | US | disclosed |
| WO-2021222287-A2 | METHODS OF IN VITRO CELL DELIVERY | INTELLIA THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |
| EP-3860972-A1 | IONIZABLE AMINE LIPIDS | Intellia Therapeutics, Inc. (US) | 2021-08-11 | — | — | EP | disclosed |
| CN-113039174-A | Ionizable amine lipids | 英特利亚治疗股份有限公司 | 2021-06-25 | — | — | CN | disclosed |
| WO-2020072605-A1 | IONIZABLE AMINE LIPIDS | INTELLIA THERAPEUTICS, INC. (US) | 2020-04-09 | — | — | WO | disclosed |
| WO-2020072605-A1 | IONIZABLE AMINE LIPIDS | INTELLIA THERAPEUTICS, INC. (US) | 2020-04-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220009878-A1 | IONIZABLE AMINE LIPIDS | PHOSPHO1, SGMS1, SGMS2 | ALDH1A1 2334/4885TP53 1352/4885TSHR 2738/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.