Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.51 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28447997 | 0.81 | GPR119 (0.53) | GPR119NPY5RHRH3FFAR1TRPV6 | |
| SCHEMBL31329886 | 0.76 | GPR119 (0.52) | GPR119HRH3TRPV6CHRNB2CHRNA4 | |
| SCHEMBL19302597 | 0.76 | GPR119 (0.52) | GPR119HRH3TRPV6CHRNB2CHRNA4 | |
| SCHEMBL5798534 | 0.74 | NOTUM (0.59) | GPR119HRH3CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL8307614 | 0.74 | GPR119 (0.47) | GPR119NPY5RHRH3CHRNB2CHRNA4 | |
| SCHEMBL27600357 | 0.73 | CHRNB2 (0.51) | GPR119HRH3TRPV6CHRNB2CHRNA4 | |
| SCHEMBL12988214 | 0.73 | CHRNB2 (0.51) | GPR119HRH3TRPV6CHRNB2CHRNA4 | |
| SCHEMBL31401347 | 0.73 | KDM4E (0.61) | GPR119NPY5RHRH3TRPV6CHRNB2 | |
| SCHEMBL30664035 | 0.73 | KDM4E (0.61) | GPR119NPY5RHRH3TRPV6CHRNB2 | |
| SCHEMBL6502064 | 0.72 | GPR119 (0.50) | GPR119NPY5RNPC1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3861000-A1 | THIENO[3,2-B]PYRIDINE DERIVATIVES AS UDP GLYCOSYLTRANSFERASE INHIBITORS AND METHODS OF USE | Genzyme Corporation (US) | 2021-08-11 | — | — | EP | disclosed |
| WO-2020072504-A1 | THIENO[3,2-B]PYRIDINE DERIVATIVES AS UDP GLYCOSYLTRANSFERASE INHIBITORS AND METHODS OF USE | GENZYME CORPORATION (US) | 2020-04-09 | — | — | WO | disclosed |