Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3600031 | 0.82 | OPRD1 (0.33) | — | |
| SCHEMBL3591820 | 0.78 | SMN1; SMN2 (0.35) | SIGMAR1SMN1; SMN2CHRM5CHRM3 | |
| SCHEMBL3590885 | 0.77 | SLC6A2 (0.33) | SIGMAR1SMN1; SMN2SLC6A2SLC6A4KCNH2 | |
| SCHEMBL596638 | 0.77 | SIGMAR1 (0.31) | SIGMAR1 | |
| SCHEMBL3582551 | 0.77 | SIGMAR1 (0.31) | SIGMAR1 | |
| SCHEMBL8183817 | 0.76 | SIGMAR1 (0.30) | SIGMAR1 | |
| SCHEMBL1819138 | 0.74 | CHRM2 (0.34) | SIGMAR1CHRM2CHRM1SLC6A2SLC6A4 | |
| SCHEMBL654110 | 0.70 | ADRB1 (0.49) | SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL27513984 | 0.69 | CHRM2 (0.32) | CHRM2CHRM1CHRM5CHRM3 | |
| SCHEMBL361322 | 0.69 | MEN1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3861000-A1 | THIENO[3,2-B]PYRIDINE DERIVATIVES AS UDP GLYCOSYLTRANSFERASE INHIBITORS AND METHODS OF USE | Genzyme Corporation (US) | 2021-08-11 | — | — | EP | disclosed |
| WO-2020072504-A1 | THIENO[3,2-B]PYRIDINE DERIVATIVES AS UDP GLYCOSYLTRANSFERASE INHIBITORS AND METHODS OF USE | GENZYME CORPORATION (US) | 2020-04-09 | — | — | WO | disclosed |