Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.74 |
| ▸ | MAPT | P10636 | 8/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.62 |
| ▸ | NPC1 | O15118 | 5/20 | 0.62 |
| ▸ | RAB9A | P51151 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.52 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12413371 | 0.92 | KDM4E (0.67) | KDM4EMAPTALDH1A1NPC1RAB9A | |
| SCHEMBL2182357 | 0.88 | KDM4E (0.58) | KDM4EMAPTALDH1A1NPC1RAB9A | |
| SCHEMBL4683758 | 0.85 | KDM4E (1.00) | KDM4EMAPTALDH1A1NPC1RAB9A | |
| SCHEMBL6506553 | 0.83 | MAPT (0.86) | KDM4EMAPTALDH1A1NPC1RAB9A | |
| SCHEMBL29768227 | 0.82 | ALDH1A1 (0.76) | KDM4EMAPTALDH1A1NPC1RAB9A | |
| SCHEMBL28566115 | 0.82 | ALDH1A1 (0.76) | KDM4EMAPTALDH1A1NPC1RAB9A | |
| SCHEMBL12413318 | 0.81 | MAPT (0.53) | KDM4EMAPTALDH1A1NPC1RAB9A | |
| SCHEMBL2184783 | 0.80 | KDM4E (0.62) | KDM4EMAPTALDH1A1NPC1RAB9A | |
| SCHEMBL2181512 | 0.79 | MAPT (0.61) | KDM4EMAPTALDH1A1NPC1RAB9A | |
| SCHEMBL7912467 | 0.78 | KDM4E (0.73) | KDM4EMAPTALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110166142-A1 | 2-SUBSTITUTED ISOFLAVONOID COMPOUNDS, MEDICAMENTS AND USES | NOVOGEN RESEARCH PTY LIMITED (AU) | 2011-07-07 | — | — | US | disclosed |
| US-20110166142-A1 | 2-SUBSTITUTED ISOFLAVONOID COMPOUNDS, MEDICAMENTS AND USES | NOVOGEN RESEARCH PTY LIMITED (AU) | 2011-07-07 | — | — | US | disclosed |
| EP-2160385-A1 | 2-SUBSTITUTED ISOFLAVONOID COMPOUNDS, MEDICAMENTS AND USES | Novogen Research Pty. Ltd. (AU) | 2010-03-10 | — | — | EP | disclosed |
| WO-2009003229-A1 | 2-SUBSTITUTED ISOFLAVONOID COMPOUNDS, MEDICAMENTS AND USES | NOVOGEN RESEARCH PTY LTD (AU) | 2009-01-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166142-A1 | 2-SUBSTITUTED ISOFLAVONOID COMPOUNDS, MEDICAMENTS AND USES | NFE2L2, PTGS2, PTGES2 | KDM4E 3142/4885MAPT 2334/4885ALDH1A1 2357/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.