Sugi Predict

Sugi Predict / Compounds / SCHEMBL21831219

SCHEMBL21831219

SCHEMBL21831219

COc1ccc(C(C)Cl)cc1O

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TUBB1 Q9H4B7 5/20 0.56
▸ TUBB4A P04350 4/20 0.56
▸ TUBB P07437 4/20 0.56
▸ TUBA3C P0DPH7 4/20 0.56
▸ TUBA1B P68363 4/20 0.56
▸ TUBA4A P68366 4/20 0.56
▸ TUBB4B P68371 4/20 0.56
▸ TUBB3 Q13509 4/20 0.56
▸ TUBB2A Q13885 4/20 0.56
▸ TUBB8 Q3ZCM7 4/20 0.56
▸ TUBA3E Q6PEY2 4/20 0.56
▸ TUBA1A Q71U36 4/20 0.56
▸ TUBA1C Q9BQE3 4/20 0.56
▸ TUBB6 Q9BUF5 4/20 0.56
▸ TUBB2B Q9BVA1 4/20 0.56
▸ ALOX15 P16050 1/20 0.51
▸ ALOX12 P18054 1/20 0.51
▸ CYP19A1 P11511 1/20 0.49
▸ GAA P10253 2/20 0.46
▸ ALDH1A1 P00352 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30910898 1.00 TUBB1 (0.56) TUBB1TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL11974256 0.84 TUBB4A (0.59) TUBB1TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL2978450 0.82 TUBB4A (0.62) TUBB1TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL9021991 0.82 ACHE (0.50) MAPTKMT2ANPSR1TDP1CYP1A2
SCHEMBL3140349 0.81 TUBB4A (0.56) TUBB1TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL21983088 0.81 TUBB1 (0.60) TUBB1TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL11562343 0.80 TUBB4A (0.64) TUBB1TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL1758822 0.80 TUBB4A (0.59) TUBB1TUBB4ATUBBTUBA3CTUBA1B
Hydrochloric Acid SCHEMBL3563549 0.79 TUBB4A (0.54) TUBB1TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL18539377 0.78 TUBB1 (0.57) TUBB1TUBB4ATUBBTUBA3CTUBA1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112654621-B Substituted naphthyridinone compounds useful as T cell activators 百时美施贵宝公司 2024-05-14 — — CN disclosed
EP-3814348-B9 SUBSTITUTED NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS BRISTOL MYERS SQUIBB CO (US) 2023-11-01 — — EP disclosed
EP-3814348-B1 SUBSTITUTED NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS BRISTOL MYERS SQUIBB CO (US) 2023-08-02 — — EP disclosed
US-11713316-B2 Substituted naphthyridinone compounds useful as T cell activators BRISTOL-MYERS SQUIBB COMPANY (US) 2023-08-01 — — US disclosed
US-11713316-B2 Substituted naphthyridinone compounds useful as T cell activators BRISTOL-MYERS SQUIBB COMPANY (US) 2023-08-01 — — US disclosed
US-11713316-B2 Substituted naphthyridinone compounds useful as T cell activators BRISTOL-MYERS SQUIBB COMPANY (US) 2023-08-01 — — US disclosed
US-20220324859-A1 SUBSTITUTED NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS BRISTOL MYERS SQUIBB CO (US) 2022-10-13 — — US disclosed
EP-3814348-A1 SUBSTITUTED NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS Bristol-Myers Squibb Company (US) 2021-05-05 — — EP disclosed
CN-112654621-A Substituted naphthyridinone compounds useful as T cell activators 百时美施贵宝公司 2021-04-13 — — CN disclosed
US-10954238-B1 Substituted naphthyridinone compounds useful as T cell activators BRISTOL-MYERS SQUIBB COMPANY (US) 2021-03-23 — — US disclosed
US-10954238-B1 Substituted naphthyridinone compounds useful as T cell activators BRISTOL-MYERS SQUIBB COMPANY (US) 2021-03-23 — — US disclosed
US-10669272-B2 Substituted naphthyridinone compounds useful as T cell activators BRISTOL-MYERS SQUIBB COMPANY (US) 2020-06-02 — — US disclosed
US-10669272-B2 Substituted naphthyridinone compounds useful as T cell activators BRISTOL-MYERS SQUIBB COMPANY (US) 2020-06-02 — — US disclosed
US-20200109140-A1 SUBSTITUTED NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS SYNGENE INTERNATIONAL LIMITED (IN) 2020-04-09 — — US disclosed
US-20200109140-A1 SUBSTITUTED NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS SYNGENE INTERNATIONAL LIMITED (IN) 2020-04-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220324859-A1 SUBSTITUTED NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS DGKZ, DGKA, DGKG TUBB1 2257/4885TUBB4A 3324/4885TUBB 2850/4885
US-20200109140-A1 SUBSTITUTED NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS DGKZ, DGKA, DGKG TUBB1 2257/4885TUBB4A 3324/4885TUBB 2850/4885
US-11713316-B2 Substituted naphthyridinone compounds useful as T cell activators DGKZ, DGKA, DGKG TUBB1 2257/4885TUBB4A 3324/4885TUBB 2850/4885
US-10669272-B2 Substituted naphthyridinone compounds useful as T cell activators DGKZ, DGKA, DGKG TUBB1 2257/4885TUBB4A 3324/4885TUBB 2850/4885
US-10954238-B1 Substituted naphthyridinone compounds useful as T cell activators DGKZ, DGKA, DGKG TUBB1 2257/4885TUBB4A 3324/4885TUBB 2850/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.