Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 6/20 | 0.53 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | GPR183 | P32249 | 1/20 | 0.43 |
| ▸ | PKLR | P30613 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21911219 | 0.83 | PKM (0.56) | PKMMMP2MEN1KMT2AALDH1A1 | |
| SCHEMBL21004687 | 0.79 | LMNA (0.46) | PKMMEN1KMT2AMAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL20511341 | 0.77 | LMNA (0.46) | PKMMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL21834214 | 0.76 | PKM (0.53) | PKMMMP2MEN1KMT2AMAPT | |
| SCHEMBL21005028 | 0.75 | PSEN1 (0.46) | POLBKDM4E | |
| SCHEMBL1711115 | 0.75 | PKM (0.85) | PKMMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL1797016 | 0.75 | MAPT (0.69) | PKMMEN1KMT2AMAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL20511356 | 0.74 | PSEN1 (0.46) | POLBKDM4E | |
| Hydrochloric Acid SCHEMBL30437494 | 0.74 | PSEN1 (0.46) | POLBKDM4E | |
| Hydrochloric Acid SCHEMBL1180894 | 0.74 | MAPT (0.67) | PKMMEN1KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113226356-B | Activation of pyruvate kinase R | 诺沃挪第克健康护理股份公司 | 2025-03-04 | — | — | CN | disclosed |
| US-20230055923-A1 | ACTIVATING PYRUVATE KINASE R | NOVO NORDISK HEALTH CARE AG (CH) | 2023-02-23 | — | — | US | disclosed |
| CN-113226356-A | Activating pyruvate kinase R | 福马治疗股份有限公司 | 2021-08-06 | — | — | CN | disclosed |
| EP-3852791-A1 | ACTIVATING PYRUVATE KINASE R | Forma Therapeutics, Inc. (US) | 2021-07-28 | — | — | EP | disclosed |
| WO-2020061255-A1 | ACTIVATING PYRUVATE KINASE R | FORMA THERAPEUTICS, INC. (US) | 2020-03-26 | — | — | WO | disclosed |
| WO-2020061255-A1 | ACTIVATING PYRUVATE KINASE R | FORMA THERAPEUTICS, INC. (US) | 2020-03-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230055923-A1 | ACTIVATING PYRUVATE KINASE R | PDK1, PDK2, PKLR | PKM 9/4885MMP2 4299/4885MEN1 4638/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.