Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.38 |
| ▸ | RAB9A | P51151 | 8/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.36 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 8/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.36 |
| ▸ | NPC1 | O15118 | 6/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27372 | 0.85 | LMNA (0.42) | ALDH1A1MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL4670361 | 0.76 | ALDH1A1 (0.37) | MAPTALDH1A1CHRNA7MEN1KMT2A | |
| SCHEMBL2637286 | 0.76 | MAPT (0.43) | MAPTRAB9AL3MBTL1CASP3SENP8 | |
| SCHEMBL9572783 | 0.73 | AOC3 (0.47) | MEN1KMT2ATSHRCYP2D6PPARA | |
| SCHEMBL10590307 | 0.73 | MAPT (0.40) | MAPTRAB9AL3MBTL1CASP3SENP8 | |
| SCHEMBL1432767 | 0.71 | AOC3 (0.39) | MEN1KMT2ASMN1; SMN2LMNATSHR | |
| SCHEMBL5515058 | 0.71 | CYP17A1 (0.39) | MAPTRAB9AALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL25447793 | 0.71 | CYP2C9 (0.50) | MAPTRAB9AL3MBTL1ALDH1A1CHRNA7 | |
| SCHEMBL6704873 | 0.70 | ALDH1A1 (0.42) | MAPTL3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL6003373 | 0.69 | POLB (0.42) | RAB9AALDH1A1NPC1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3846824-A2 | COMPOSITIONS AND METHODS FOR IMMUNE CHECKPOINT INHIBITION | The General Hospital Corporation (US) | 2021-07-14 | — | — | EP | disclosed |
| WO-2020068398-A2 | COMPOSITIONS AND METHODS FOR IMMUNE CHECKPOINT INHIBITION | THE GENERAL HOSPITAL CORPORATION (US) | 2020-04-02 | — | — | WO | disclosed |