Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biphenyl SCHEMBL28193720 | 0.78 | ALDH1A1 (0.43) | ALDH1A1L3MBTL1SMN1; SMN2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL29427302 | 0.78 | ALDH1A1 (0.90) | ALDH1A1HSD17B10L3MBTL1SMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL15571781 | 0.78 | ALDH1A1 (0.90) | ALDH1A1HSD17B10L3MBTL1SMN1; SMN2LMNA | |
| SCHEMBL30985618 | 0.76 | ALDH1A1 (0.94) | ALDH1A1HSD17B10L3MBTL1SMN1; SMN2LMNA | |
| SCHEMBL29539416 | 0.76 | ALDH1A1 (0.94) | ALDH1A1HSD17B10L3MBTL1SMN1; SMN2LMNA | |
| SCHEMBL11298718 | 0.74 | ALDH1A1 (0.55) | ALDH1A1HSD17B10L3MBTL1SMN1; SMN2MEN1 | |
| SCHEMBL28465796 | 0.74 | ALDH1A1 (1.00) | ALDH1A1HSD17B10L3MBTL1SMN1; SMN2LMNA | |
| SCHEMBL29407079 | 0.74 | ALDH1A1 (1.00) | ALDH1A1HSD17B10L3MBTL1SMN1; SMN2LMNA | |
| SCHEMBL25981 | 0.74 | ALDH1A1 (1.00) | ALDH1A1HSD17B10L3MBTL1SMN1; SMN2LMNA | |
| Benzene SCHEMBL28328298 | 0.74 | ALDH1A1 (1.00) | ALDH1A1HSD17B10L3MBTL1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210355086-A1 | PROCESS FOR PREPARING A NOVEL PHENICOL ANTIBACTERIAL AGENT | ZOETIS SERVICES LLC | 2021-11-18 | — | — | US | disclosed |
| EP-3856718-A1 | PROCESS FOR PREPARING THE COMPOUND 2,2-DIFLUORO-N-((1R,2S)-3-FLUORO-1-HYDROXY-1-(4-(6-(S-METHYLSULFONIMIDOYL)PYRIDIN-3-YL)PHENYL)PROPAN-2-YL)ACETAMIDE | Zoetis Services LLC (US) | 2021-08-04 | — | — | EP | disclosed |
| WO-2020068607-A1 | PROCESS FOR PREPARING THE COMPOUND 2,2-DIFLUORO-N-((1R,2S)-3-FLUORO-1-HYDROXY-1-(4-(6-(S-METHYLSULFONIMIDOYL)PYRIDIN-3-YL)PHENYL)PROPAN-2-YL)ACETAMIDE | ZOETIS SERVICES LLC. (US) | 2020-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210355086-A1 | PROCESS FOR PREPARING A NOVEL PHENICOL ANTIBACTERIAL AGENT | CYP1A1, P4HA1, MRPL21 | ALDH1A1 510/4885HSD17B10 1910/4885L3MBTL1 2539/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.