SCHEMBL2183577

SCHEMBL2183577

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nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BMP1 P13497 2/20 0.43
DPP4 P27487 1/20 0.41
DPP8 Q6V1X1 1/20 0.41
DPP9 Q86TI2 1/20 0.41
ENPEP Q07075 7/20 0.40
ANPEP P15144 4/20 0.40
FOLH1 Q04609 1/20 0.38
GABRP O00591 2/20 0.35
GABRD O14764 2/20 0.35
GABRA1 P14867 2/20 0.35
GABRB1 P18505 2/20 0.35
GABRG2 P18507 2/20 0.35
GABRB3 P28472 2/20 0.35
GABRA5 P31644 2/20 0.35
GABRA3 P34903 2/20 0.35
GABRA2 P47869 2/20 0.35
GABRB2 P47870 2/20 0.35
GABRA4 P48169 2/20 0.35
GABRE P78334 2/20 0.35
GABRA6 Q16445 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16468616 0.84 DPP4 (0.56) DPP4DPP8DPP9ENPEPANPEP
SCHEMBL29893483 0.80 BMP1 (0.48) BMP1DPP4DPP8DPP9ENPEP
SCHEMBL29672150 0.80 FOLH1 (0.58) BMP1ENPEPANPEPFOLH1
SCHEMBL23857929 0.80 FOLH1 (0.58) BMP1ENPEPANPEPFOLH1
SCHEMBL29379297 0.80 FOLH1 (0.58) BMP1ENPEPANPEPFOLH1
SCHEMBL7405823 0.80 DPP4 (0.43) BMP1DPP4DPP8DPP9ENPEP
SCHEMBL2197913 0.79 DPP4 (0.48) BMP1DPP4DPP8DPP9ENPEP
SCHEMBL29726669 0.78 ENPEP (0.49) BMP1DPP4DPP8DPP9ENPEP
SCHEMBL29977859 0.78 FOLH1 (0.58) BMP1DPP4DPP8DPP9FOLH1
SCHEMBL29893864 0.78 FOLH1 (0.58) BMP1DPP4DPP8DPP9FOLH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8680263-B2 Carbohydrate-based drug delivery polymers and conjugates thereof NEKTAR THERAPEUTICS (US) 2014-03-25 US disclosed
US-20110171716-A1 CARBOHYDRATE-BASED DRUG DELIVERY POLYMERS AND CONJUGATES THEREOF NEKTAR THERAPEUTICS (US) 2011-07-14 US disclosed
US-20110166063-A1 POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES NEKTAR THERAPEUTICS (US) 2011-07-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110171716-A1 CARBOHYDRATE-BASED DRUG DELIVERY POLYMERS AND CONJUGATES THEREOF STT3B, STT3A, DDOST BMP1 2155/4885DPP4 193/4885DPP8 274/4885
US-20110166063-A1 POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES NGLY1, CD44, IAPP BMP1 3740/4885DPP4 525/4885DPP8 644/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.