Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17683993 | 0.80 | TSHR (0.39) | NPSR1CHRM2CHRM1CHRM3CHRM4 | |
| SCHEMBL5202981 | 0.79 | ALDH1A1 (0.45) | SMN1; SMN2NPSR1CHRM2CHRM1CHRM3 | |
| SCHEMBL14463170 | 0.77 | ALDH1A1 (0.47) | SMN1; SMN2NPSR1LMNACYP3A4TSHR | |
| SCHEMBL1812214 | 0.76 | ALOX15 (0.39) | SMN1; SMN2LMNATSHRCYP1A2KCNH2 | |
| SCHEMBL1837607 | 0.76 | ALOX15 (0.39) | SMN1; SMN2LMNATSHRCYP1A2KCNH2 | |
| Hydrochloric Acid SCHEMBL242120 | 0.74 | SMN1; SMN2 (0.38) | SMN1; SMN2NPSR1CYP3A4CYP1A2MEN1 | |
| Hydrochloric Acid SCHEMBL1812212 | 0.74 | SMN1; SMN2 (0.38) | SMN1; SMN2NPSR1CYP3A4CYP1A2MEN1 | |
| SCHEMBL2507803 | 0.74 | ALOX15 (0.41) | SMN1; SMN2LMNACYP1A2KCNH2HSD17B10 | |
| SCHEMBL23871121 | 0.73 | CYP3A4 (0.32) | NPSR1CHRM2CHRM1CHRM3CHRM4 | |
| SCHEMBL8236200 | 0.73 | TSHR (0.34) | NPSR1CHRM2CHRM1CHRM3CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464273-B9 | IMIDAZOLONE COMPOUNDS AS HUMAN NEUTROPHIL ELASTASE INHIBITORS | CHIESI FARM SPA (IT) | 2020-10-21 | — | — | EP | disclosed |
| EP-3464273-B1 | IMIDAZOLONE COMPOUNDS AS HUMAN NEUTROPHIL ELASTASE INHIBITORS | CHIESI FARM SPA (IT) | 2020-04-08 | — | — | EP | disclosed |