Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 2/20 | 0.34 |
| ▸ | TDO2 | P48775 | 2/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
| ▸ | RXRG | P48443 | 1/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.33 |
| ▸ | PNMT | P11086 | 1/20 | 0.32 |
| ▸ | KLRK1 | P26718 | 1/20 | 0.31 |
| ▸ | MICA | Q29983 | 1/20 | 0.31 |
| ▸ | RAET1L | Q5VY80 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
| ▸ | TACR1 | P25103 | 2/20 | 0.30 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5778880 | 0.85 | CES2 (0.48) | CES2IDO1TDO2PNMTTACR1 | |
| SCHEMBL30705303 | 0.80 | IDO1 (0.33) | CES2IDO1TDO2RXRARXRB | |
| SCHEMBL17449150 | 0.80 | GABRA1 (0.34) | — | |
| SCHEMBL8127537 | 0.80 | PDE2A (0.35) | IDO1TDO2RXRARXRBRXRG | |
| SCHEMBL4461544 | 0.77 | CES2 (0.48) | CES2IDO1RXRARXRBRXRG | |
| SCHEMBL9693899 | 0.77 | CES2 (0.42) | CES2IDO1RXRARXRBRXRG | |
| SCHEMBL25429733 | 0.77 | RXRA (0.35) | IDO1TDO2RXRARXRBRXRG | |
| SCHEMBL1295467 | 0.77 | TACR1 (0.33) | IDO1TDO2RXRARXRBRXRG | |
| SCHEMBL17069190 | 0.77 | PDE2A (0.37) | IDO1TDO2RXRARXRBRXRG | |
| SCHEMBL21297480 | 0.77 | TACR1 (0.33) | IDO1TDO2RXRARXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110166132-A1 | Gamma Secretase Modulators | AMGEN INC. (US) | 2011-07-07 | — | — | US | disclosed |
| CN-101896461-A | Gamma secretase modulators | AMGEN INC | 2010-11-24 | — | — | CN | disclosed |
| EP-2231602-A1 | GAMMA SECRETASE MODULATORS | Amgen, Inc (US) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009075874-A1 | GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-06-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166132-A1 | Gamma Secretase Modulators | BACE1, BACE2, PSEN1 | CES2 2255/4885IDO1 4594/4885TDO2 4772/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.