Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL7567125 | 0.81 | LMNA (0.67) | MEN1LMNAKMT2AS1PR2S1PR4 | |
| Tromethamine SCHEMBL4735605 | 0.79 | MEN1 (0.56) | MEN1LMNAKMT2ATDP1 | |
| Tromethamine SCHEMBL4737664 | 0.79 | MEN1 (0.56) | MEN1LMNAKMT2ATDP1 | |
| Tromethamine SCHEMBL8334055 | 0.76 | LMNA (0.59) | MEN1LMNAKMT2ATDP1 | |
| Tromethamine SCHEMBL9363390 | 0.76 | MEN1 (0.59) | MEN1LMNAKMT2ATDP1 | |
| Tromethamine SCHEMBL21747695 | 0.75 | MEN1 (0.43) | MEN1LMNAKMT2AS1PR2S1PR4 | |
| Tromethamine SCHEMBL3995787 | 0.74 | MEN1 (0.91) | MEN1LMNAKMT2AKDM4EPOLB | |
| Tromethamine SCHEMBL112367 | 0.74 | — | — | |
| Tromethamine SCHEMBL4388579 | 0.74 | — | — | |
| Ammonia Solution, Strong SCHEMBL28208580 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3636720-A1 | USE OF A THICKENED ALCOHOLIC COMPOSITION FOR VERTICAL, BUBBLE-FREE ADHESION OF SUBSTRATES AND METHOD FOR VERTICALLY JOINING TWO SUBSTRATES | tesa SE (DE) | 2020-04-15 | — | — | EP | disclosed |
| CN-110964445-A | Use of a thickened alcohol-containing composition for bubble-free vertical adhesion of substrates and method for vertically joining two substrates | 德莎欧洲股份公司 | 2020-04-07 | — | — | CN | disclosed |