Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL3995787 | 1.00 | MEN1 (0.91) | — | |
| Tromethamine SCHEMBL1417748 | 0.96 | MEN1 (0.83) | — | |
| Tromethamine SCHEMBL975 | 0.95 | — | — | |
| Tromethamine SCHEMBL17484 | 0.95 | MEN1 (1.00) | — | |
| Tromethamine SCHEMBL3696191 | 0.95 | — | — | |
| Tromethamine SCHEMBL4950340 | 0.92 | MEN1 (0.77) | — | |
| Tromethamine SCHEMBL6427079 | 0.91 | — | — | |
| Tromethamine SCHEMBL7126002 | 0.91 | — | — | |
| Tromethamine SCHEMBL7091147 | 0.91 | — | — | |
| Tromethamine SCHEMBL6063594 | 0.91 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 293 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118806690-A | In-situ gel preparation and application thereof | 润佳（苏州）医药科技有限公司 | 2024-10-22 | — | — | CN | claimed |
| CN-117488341-A | Self-supporting catalyst for producing hydrogen by electrolyzing water and preparation method thereof | 江苏天合元氢科技有限公司 | 2024-02-02 | — | — | CN | claimed |
| US-20230149285-A1 | DENTAL COMPOSITION COMPRISING CHELATOR AND BASE | PRIMAL THERAPIES, INC. | 2023-05-18 | — | — | US | claimed |
| US-11491100-B2 | Dermal composition comprising chelator and base | PRIMAL THERAPIES, INC. (US) | 2022-11-08 | — | — | US | claimed |
| US-20190262255-A1 | DENTAL COMPOSITION COMPRISING CHELATOR AND BASE | PRIMAL THERAPIES, INC. | 2019-08-29 | — | — | US | claimed |
| US-20160030327-A1 | DENTAL COMPOSITION COMPRISING CHELATOR AND BASE | ABOVA FINANCIAL, INC. | 2016-02-04 | — | — | US | claimed |
| EP-2968083-A1 | DENTAL COMPOSITION COMPRISING CHELATOR AND BASE | Stein, Emily A. (US) | 2016-01-20 | — | — | EP | claimed |
| CN-104125962-A | Tetracyclic anthraquinone derivatives | TIANJIN HEMAY BIO TECH CO LTD | 2014-10-29 | — | — | CN | claimed |
| WO-2014159659-A1 | DENTAL COMPOSITION COMPRISING CHELATOR AND BASE | STEIN EMILY A (US) | 2014-10-02 | — | — | WO | claimed |
| US-20090236571-A1 | STABLE, WATER-SOLUBLE NEAR INFRARED DYES | EPOLIN, INC. | 2009-09-24 | — | — | US | claimed |
| US-5624546-A | Method and apparatus for the detection of toxic gases | MIL-RAM TECHNOLOGY, INC. (US) | 1997-04-29 | — | — | US | claimed |
| US-5348159-A | Enhancement of polycyanoacrylate-developed fingerprints | HER MAJESTY THE QUEEN IN RIGHT OF CANADA AS REPRESENTED BY THE SOLICITOR GENERAL OF CANADA (CA) | 1994-09-20 | — | — | US | claimed |
| EP-4660194-A1 | SALT AND CRYSTAL FORM OF CYCLOALKENE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. (CN) | 2025-12-10 | — | — | EP | disclosed |
| US-20250340544-A1 | GLP-1 Receptor Agonists and Uses Thereof | PFIZER INC. (US) | 2025-11-06 | — | — | US | disclosed |
| US-12378230-B2 | GLP-1 receptor agonists and uses thereof | PFIZER INC. (US) | 2025-08-05 | — | — | US | disclosed |
| EP-4219487-B9 | GLP-1 RECEPTOR AGONISTS AND USES THEREOF | PFIZER (US) | 2025-03-26 | — | — | EP | disclosed |
| WO-1989005798-A1 | TROMETHAMINE SALT OF 1-METHYL-beta-OXO-alpha-(PHENYLCARBAMOYL)-2-PYRROLEPROPIONITRILE | CIBA-GEIGY AG (CH) | 1989-06-29 | — | — | WO | disclosed |
| US-4231750-A | Methods for performing chemical assays using fluorescence and photon counting | DIAGNOSTIC REAGENTS, INC. (US) | 1980-11-04 | — | — | US | disclosed |
| US-4211845-A | 3,3',5,5'-TETRAMETHYLBENZIDINE AND SYRINGALDAZINE AS CHROMOGENS | MILES LABORATORIES, INC. (US) | 1980-07-08 | — | — | US | disclosed |
| US-3959289-A | PROPHYLACTICS IN ALLERGIES | THE UPJOHN COMPANY (US) | 1976-05-25 | — | — | US | disclosed |