Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.64 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.50 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL42114 | 0.96 | AKR1C1 (0.70) | AKR1C1HDAC4MEN1KMT2AHSD11B1 | |
| SCHEMBL43810 | 0.94 | AKR1C1 (0.68) | AKR1C1HDAC4MEN1KMT2AHSD11B1 | |
| SCHEMBL501923 | 0.91 | AKR1C1 (0.57) | AKR1C1HDAC4MEN1KMT2AHSD11B1 | |
| SCHEMBL2722547 | 0.91 | AKR1C1 (0.57) | AKR1C1HDAC4MEN1KMT2AHSD11B1 | |
| Hydrochloric Acid SCHEMBL1804765 | 0.89 | AKR1C1 (0.55) | AKR1C1HDAC4MEN1KMT2AHSD11B1 | |
| SCHEMBL4560518 | 0.84 | AKR1C1 (0.47) | AKR1C1HDAC4MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3113268 | 0.83 | AKR1C1 (0.69) | AKR1C1HDAC4MEN1KMT2AHSD11B1 | |
| SCHEMBL1667343 | 0.83 | AKR1C1 (0.91) | AKR1C1HDAC4MEN1KMT2AHSD11B1 | |
| SCHEMBL2703559 | 0.82 | ALDH1A1 (0.58) | AKR1C1OPRL1SMN1; SMN2LMNANPSR1 | |
| SCHEMBL8366154 | 0.82 | OPRL1 (0.56) | AKR1C1HDAC4MEN1KMT2AHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116375549-A | Method and system for synthesizing amide compound from nitrile compound | 深圳湾实验室 | 2023-07-04 | — | — | CN | claimed |
| CN-109563085-B | Piperidine CXCR7 receptor modulators | 爱杜西亚药品有限公司 | 2022-08-09 | — | — | CN | claimed |
| EP-3490986-B1 | PIPERIDINE CXCR7 RECEPTOR MODULATORS | IDORSIA PHARMACEUTICALS LTD (CH) | 2021-11-24 | — | — | EP | claimed |
| US-10752620-B2 | Piperdine CXCR7 receptor modulators | IDORSIA PHARMACEUTICALS LTD. (CH) | 2020-08-25 | — | — | US | claimed |
| US-20190169180-A1 | PIPERDINE CXCR7 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD. (CH) | 2019-06-06 | — | — | US | claimed |
| EP-3490986-A1 | PIPERIDINE CXCR7 RECEPTOR MODULATORS | Idorsia Pharmaceuticals Ltd (CH) | 2019-06-05 | — | — | EP | claimed |
| CN-109563085-A | piperidine CXCR7 receptor modulators | 爱杜西亚药品有限公司 | 2019-04-02 | — | — | CN | claimed |
| WO-2018019929-A1 | PIPERIDINE CXCR7 RECEPTOR MODULATORS | IDORSIA PHARMACEUTICALS LTD (CH) | 2018-02-01 | — | — | WO | claimed |
| EP-3057964-A1 | SELECTIVELY SUBSTITUTED QUINOLINE COMPOUNDS | Eisai R&D Management Co., Ltd. (JP) | 2016-08-24 | — | — | EP | claimed |
| EP-2261203-B1 | PHENYLCYCLOBUTYLAMIDE DERIVATIVES AND THEIR STEREOISOMERS, THE PREPARING PROCESSES AND THE USES THEREOF | BEIJING YINGU CENTURY PHARMACY CO LTD (CN) | 2016-05-25 | — | — | EP | claimed |
| CN-104854083-A | Aminocyclobutane derivatives, process for their preparation and their use as medicaments | PF MEDICAMENT | 2015-08-19 | — | — | CN | claimed |
| WO-2015057659-A1 | SELECTIVELY SUBSTITUTED QUINOLINE COMPOUNDS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-23 | — | — | WO | claimed |
| US-8673981-B2 | Phenylcyclobutylamide derivatives and their stereoisomers, the preparation processes and uses thereof | YinGu Pharmaceutical Co., Ltd (CN) | 2014-03-18 | — | — | US | claimed |
| US-20130289124-A1 | PHENYLCYCLOBUTYLAMIDE DERIVATIVES AND THEIR STEREOISOMERS, THE PREPARATION PROCESSES AND USES THEREOF | YinGu Pharmaceutical Co., Ltd (CN) | 2013-10-31 | — | — | US | claimed |
| US-8497305-B2 | Phenylcyclobutylamide derivatives and their stereoisomers, the preparation processes and uses thereof | YinGu Pharmaceutical Co., Ltd (CN) | 2013-07-30 | — | — | US | claimed |
| US-20110224305-A1 | PHENYLCYCLOBUTYLAMIDE DERIVATIVES AND THEIR STEREOISOMERS, THE PREPARATION PROCESSES AND USES THEREOF | BEIJING YINGU CENTURY PHARMACY CO. LTD (CN) | 2011-09-15 | — | — | US | claimed |
| EP-2261203-A1 | PHENYLCYCLOBUTYLAMIDE DERIVATIVES AND THEIR STEREOISOMERS, THE PREPARING PROCESSES AND THE USES THEREOF | Beijing Cachet Biomedical Co., Ltd (CN) | 2010-12-15 | — | — | EP | claimed |
| CN-116528857-A | MALT-1 modulators | 艾克斯赛安西娅人工智能有限公司 | 2023-08-01 | — | — | CN | disclosed |
| EP-1490043-A2 | SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003082190-A2 | SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2003-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224305-A1 | PHENYLCYCLOBUTYLAMIDE DERIVATIVES AND THEIR STEREOISOMERS, THE PREPARATION PROCESSES AND USES THEREOF | AADAC, WIZ, CEBPZ | AKR1C1 3650/4885HDAC4 292/4885MEN1 4756/4885 |
| US-20190169180-A1 | PIPERDINE CXCR7 RECEPTOR MODULATORS | CXCR1, CXCR5, ACKR3 | AKR1C1 1299/4885HDAC4 2022/4885MEN1 4254/4885 |
| US-20130289124-A1 | PHENYLCYCLOBUTYLAMIDE DERIVATIVES AND THEIR STEREOISOMERS, THE PREPARATION PROCESSES AND USES THEREOF | AADAC, WIZ, CEBPZ | AKR1C1 3650/4885HDAC4 292/4885MEN1 4756/4885 |
| US-10752620-B2 | Piperdine CXCR7 receptor modulators | CXCR1, CXCR5, ACKR3 | AKR1C1 1299/4885HDAC4 2022/4885MEN1 4254/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.