Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 11/20 | 0.40 |
| ▸ | JAK2 | O60674 | 6/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 5/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19218078 | 0.87 | FAAH (0.33) | JAK1JAK2SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL13127914 | 0.81 | FFAR1 (0.33) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL15292346 | 0.77 | FFAR1 (0.47) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL19218101 | 0.76 | KIT (0.33) | — | |
| SCHEMBL23193842 | 0.76 | KAT2B (0.33) | ALDH1A1 | |
| SCHEMBL1899263 | 0.76 | JAK1 (0.39) | JAK1JAK2TYK2GSK3AGSK3B | |
| SCHEMBL12179505 | 0.75 | ACHE (0.43) | — | |
| SCHEMBL21746173 | 0.74 | L3MBTL1 (0.30) | — | |
| SCHEMBL12997514 | 0.74 | CYP2C9 (0.47) | JAK1JAK2MITFMAPK1TYK2 | |
| SCHEMBL14125781 | 0.74 | GSK3A (0.44) | JAK1JAK2MITFMAPK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020069106-A1 | DEGRADERS THAT TARGET ALK AND THERAPEUTIC USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-04-02 | — | — | WO | disclosed |