Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.49 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21844897 | 0.89 | NPC1 (0.51) | TMEM97SIGMAR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21844826 | 0.83 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL21844862 | 0.81 | MEN1 (0.59) | RAB9ASMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL20083997 | 0.80 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL15276915 | 0.77 | LMNA (0.60) | NPC1RAB9ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL20083991 | 0.74 | GRM4 (0.46) | NPC1RAB9ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL3675463 | 0.74 | KCNK3 (0.84) | NPC1RAB9ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL21844896 | 0.74 | PARP1 (0.49) | NPC1RAB9ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL2065025 | 0.73 | CYP3A4 (0.44) | CA1 | |
| SCHEMBL30802691 | 0.73 | KCNK3 (0.68) | NPC1RAB9AMEN1KMT2AKCNK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3312160-B1 | HEPATITIS B ANTIVIRAL AGENTS | NOVIRA THERAPEUTICS INC (US) | 2020-03-18 | — | — | EP | disclosed |