Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20083999 | 0.94 | KDR (0.43) | KDRLMNAMEN1KMT2ATHRB | |
| SCHEMBL20083950 | 0.87 | KDR (0.46) | KDRLMNAMEN1KMT2ATHRB | |
| SCHEMBL21844896 | 0.82 | PARP1 (0.49) | KDRLMNAMEN1KMT2AROCK2 | |
| SCHEMBL21844897 | 0.77 | NPC1 (0.51) | LMNAMEN1KMT2ANPC1TP53 | |
| SCHEMBL20083997 | 0.76 | NPC1 (0.53) | LMNAMEN1KMT2AKDM4ENPC1 | |
| SCHEMBL19157203 | 0.74 | KDR (0.46) | KDRLMNAMEN1KMT2AROCK2 | |
| SCHEMBL21844862 | 0.74 | MEN1 (0.59) | LMNAMEN1KMT2ATHRBKDM4E | |
| SCHEMBL20084035 | 0.73 | KCNK3 (0.69) | MEN1KMT2ATHRBNPC1TP53 | |
| SCHEMBL20083991 | 0.72 | GRM4 (0.46) | KDRLMNAMEN1KMT2AROCK2 | |
| SCHEMBL15276968 | 0.71 | LMNA (0.52) | KDRLMNAMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3312160-B1 | HEPATITIS B ANTIVIRAL AGENTS | NOVIRA THERAPEUTICS INC (US) | 2020-03-18 | — | — | EP | disclosed |