Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD3 | Q99594 | 1/20 | 0.37 |
| ▸ | KRAS | P01116 | 10/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.32 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22087281 | 0.90 | KRAS (0.40) | TEAD3KRASJAK3BTK | |
| SCHEMBL21912079 | 0.79 | BTK (0.37) | KRASJAK3BTK | |
| SCHEMBL21895605 | 0.77 | KRAS (0.43) | TEAD3KRASJAK3BTK | |
| SCHEMBL22994789 | 0.75 | KRAS (0.44) | TEAD3KRASJAK3FGFR1FGFR2 | |
| SCHEMBL21912197 | 0.74 | HPGD (0.32) | FGFR1FGFR2 | |
| SCHEMBL21896284 | 0.73 | KRAS (0.40) | KRASJAK3BTK | |
| SCHEMBL21895629 | 0.71 | KRAS (0.38) | TEAD3KRASJAK3BTK | |
| SCHEMBL21846333 | 0.70 | KRAS (0.45) | TEAD3KRAS | |
| SCHEMBL22994733 | 0.70 | JAK3 (0.40) | TEAD3KRASJAK3BTK | |
| SCHEMBL19636773 | 0.68 | KRAS (0.75) | KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020055760-A1 | COMBINATION THERAPIES | Mirati Therapeutics, Inc. (US) | 2020-03-19 | — | — | WO | disclosed |