Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 13/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22994767 | 0.88 | BTK (0.44) | KRASBTKKMT2ANUDT1JAK3 | |
| SCHEMBL21895605 | 0.87 | KRAS (0.43) | KRASBTKJAK3 | |
| SCHEMBL22994789 | 0.85 | KRAS (0.44) | KRASNUDT1JAK3 | |
| SCHEMBL22994733 | 0.84 | JAK3 (0.40) | KRASBTKNUDT1JAK3 | |
| SCHEMBL21895629 | 0.82 | KRAS (0.38) | KRASBTKJAK3 | |
| SCHEMBL22994731 | 0.81 | NUDT1 (0.38) | KRASBTKNUDT1JAK3 | |
| SCHEMBL21846319 | 0.81 | KRAS (0.46) | KRAS | |
| SCHEMBL22994683 | 0.81 | KRAS (0.46) | KRAS | |
| SCHEMBL21895574 | 0.80 | KRAS (0.39) | KRASBTKJAK3 | |
| SCHEMBL22088501 | 0.76 | BTK (0.50) | KRASBTKJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020055756-A1 | COMBINATION THERAPIES | Mirati Therapeutics, Inc. (US) | 2020-03-19 | — | — | WO | disclosed |