Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 3/20 | 0.37 |
| ▸ | TEC | P42680 | 2/20 | 0.37 |
| ▸ | KRAS | P01116 | 7/20 | 0.35 |
| ▸ | JAK3 | P52333 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | TET3 | O43151 | 1/20 | 0.32 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.32 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.32 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.32 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.32 |
| ▸ | CXXC4 | Q9H2H0 | 1/20 | 0.32 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22087281 | 0.81 | KRAS (0.40) | BTKKRASJAK3 | |
| SCHEMBL21846179 | 0.79 | TEAD3 (0.37) | BTKKRASJAK3 | |
| SCHEMBL22994767 | 0.72 | BTK (0.44) | BTKKRASJAK3KMT2ATET3 | |
| SCHEMBL23156744 | 0.71 | KRAS (0.43) | BTKKRASKMT2ATET3FBXL19 | |
| SCHEMBL21733675 | 0.71 | KRAS (0.43) | KRAS | |
| SCHEMBL22994731 | 0.70 | NUDT1 (0.38) | BTKKRASJAK3 | |
| SCHEMBL21896284 | 0.70 | KRAS (0.40) | BTKKRASJAK3KMT2AMEN1 | |
| SCHEMBL23156770 | 0.69 | KRAS (0.44) | BTKKRASKMT2ATET3FBXL19 | |
| SCHEMBL22994733 | 0.65 | JAK3 (0.40) | BTKKRASJAK3 | |
| SCHEMBL21733862 | 0.65 | KRAS (0.41) | KRASKMT2ATET3FBXL19CXXC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020055755-A1 | COMBINATION THERAPIES | Mirati Therapeutics, Inc. (US) | 2020-03-19 | — | — | WO | disclosed |