Sugi Predict

Sugi Predict / Compounds / SCHEMBL2184643

SCHEMBL2184643

SCHEMBL2184643

O=C1OC2(c3ccc(O)cc3Oc3cc(O)ccc32)c2cccc(CBr)c21

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ FTO Q9C0B1 10/20 0.59
▸ MAPT P10636 3/20 0.59
▸ HPGD P15428 2/20 0.59
▸ MEN1 O00255 2/20 0.59
▸ HTT P42858 2/20 0.59
▸ KMT2A Q03164 2/20 0.59
▸ CYP2C19 P33261 1/20 0.59
▸ RECQL P46063 1/20 0.59
▸ BLM P54132 1/20 0.59
▸ SMAD3 P84022 1/20 0.59
▸ PRMT1 Q99873 1/20 0.59
▸ ACE2 Q9BYF1 1/20 0.59
▸ TDP1 Q9NUW8 1/20 0.59
▸ ALDH1A1 P00352 2/20 0.56
▸ ALOX12 P18054 2/20 0.56
▸ CYP2C9 P11712 1/20 0.56
▸ ALOX15 P16050 1/20 0.56
▸ BRCA1 P38398 1/20 0.56
▸ HSD17B10 Q99714 1/20 0.56
▸ LMNA P02545 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4743773 0.89 FTO (0.60) FTOMAPTHPGDMEN1HTT
SCHEMBL2314510 0.89 FTO (0.60) FTOMAPTHPGDMEN1HTT
SCHEMBL84112 0.88 FTO (0.59) FTOMAPTHPGDMEN1HTT
SCHEMBL336896 0.88 FTO (0.59) FTOMAPTHPGDMEN1HTT
SCHEMBL19546123 0.87 FTO (0.55) FTOMAPTHPGDMEN1HTT
Hydrochloric Acid SCHEMBL7640824 0.86 FTO (0.57) FTOMAPTHPGDMEN1HTT
SCHEMBL4825622 0.85 FTO (0.56) FTOMAPTHPGDMEN1HTT
SCHEMBL22110384 0.85 FTO (0.56) FTOMAPTHPGDMEN1HTT
SCHEMBL1115891 0.85 HPGD (0.57) FTOMAPTHPGDMEN1HTT
SCHEMBL7647553 0.85 FTO (0.56) FTOMAPTHPGDMEN1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7759069-B1 Compositions and methods for measuring nuclear receptor ligands CORNELL RESEARCH FOUNDATION, INC. (US) 2010-07-20 — — US claimed
EP-1851542-A1 USE OF THIOPEPTOLIDES FOR DETERMINING THE ACTIVITY OF ADAMTS PROTEASES Sanofi-Aventis (FR) 2007-11-07 — — EP claimed
WO-2006092203-A1 USE OF THIOPEPTOLIDES FOR DETERMINING THE ACTIVITY OF ADAMTS PROTEASES SANOFI-AVENTIS (DE) 2006-09-08 — — WO claimed
CN-109111913-B A kind of pair of transmitting cellulose base fluorescent material and its preparation method and application 中国科学院化学研究所 2019-10-01 — — CN disclosed
CN-109111913-A A kind of pair of transmitting cellulose base fluorescent material and its preparation method and application 中国科学院化学研究所 2019-01-01 — — CN disclosed
US-20120232104-A1 NOVEL SULFONAMIDES AS L-CPT1 INHIBITORS BLEICHER KONRAD (DE) 2012-09-13 — — US disclosed
US-20110319438-A1 NOVEL SULFONAMIDES AS L-CPT1 INHIBITORS BLEICHER KONRAD (DE) 2011-12-29 — — US disclosed
EP-2343383-A1 New detector probe acting by molecular recognition Biomérieux (FR) 2011-07-13 — — EP disclosed
US-7759069-B1 Compositions and methods for measuring nuclear receptor ligands CORNELL RESEARCH FOUNDATION, INC. (US) 2010-07-20 — — US disclosed
US-20100144762-A1 NOVEL SULFONAMIDES AS L-CPT1 INHIBITORS BLEICHER KONRAD 2010-06-10 — — US disclosed
US-7723538-B2 enzyme inhibitors of membrane-bound carnitine-dependent palmitoyltransferases (CPTs); inhibit gluconeogenesis and therefore counteract hyperglycemia; 4-(3-Benzenesulfonylamino-benzoylamino)-benzoic acid HOFFMANN-LA ROCHE INC. (US) 2010-05-25 — — US disclosed
US-7338805-B2 Labeling reagents, methods for synthesizing such reagents and methods for detecting biological molecules BIO MERIEUX (FR) 2008-03-04 — — US disclosed
EP-1891001-A1 SULFONAMIDE DERIVATIVES USEFUL AS LIVER CARNITINE PALMITOYL TRANSFERASE (L-CPTl) INHIBITORS F. Hoffmann-Roche AG (CH) 2008-02-27 — — EP disclosed
WO-2006131452-A1 SULFONAMIDE DERIVATIVES USEFUL AS LIVER CARNITINE PALMITOYL TRANSFERASE (L-CPTl) INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2006-12-14 — — WO disclosed
US-20060276494-A1 Novel sulfonamides as L-CPT1 inhibitors F. HOFFMANN-LA ROCHE AG (CH) 2006-12-07 — — US disclosed
US-7060441-B2 Method for fragmenting and labeling DNA involving abasic sites and phosphate labeling BIOMERIEUX (FR) 2006-06-13 — — US disclosed
US-6902891-B2 Process for labeling a nucleic acid BIO MERIEUX (FR) 2005-06-07 — — US disclosed
WO-2004001414-A1 FLUORESCENT MAGNETIC NANOPARTICLES bioMérieux (FR) 2003-12-31 — — WO disclosed
US-20020081586-A1 Process for labeling a nucleic acid HOLOGIC, INC. 2002-06-27 — — US disclosed
US-5420228-A PROBE FOR DETECTING THE INTRACELLULAR UPTAKE AND DISTRIBUTION OF A TALISOMYCIN UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 1995-05-30 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060276494-A1 Novel sulfonamides as L-CPT1 inhibitors CPT1A, CPT1B, CPT2 FTO 1695/4885MAPT 2667/4885HPGD 1616/4885
US-20120232104-A1 NOVEL SULFONAMIDES AS L-CPT1 INHIBITORS CPT1A, CPT1B, CPT2 FTO 1695/4885MAPT 2667/4885HPGD 1616/4885
US-20100144762-A1 NOVEL SULFONAMIDES AS L-CPT1 INHIBITORS CPT1A, CPT1B, CPT2 FTO 1695/4885MAPT 2667/4885HPGD 1616/4885
US-20110319438-A1 NOVEL SULFONAMIDES AS L-CPT1 INHIBITORS CPT1A, CPT1B, CPT2 FTO 1695/4885MAPT 2667/4885HPGD 1616/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.